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Gynheung An, Ph.D.
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Professor
Department of Life
Science
Division of Molecular and Life Sciences
Plant
Development
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Publications
Abstract
E-mail genean@postech.ac.kr
Phone +82-54-279-2176(office)
+82-54-279-5995(lab.)
Laboratory Plant
Functional Genomics
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Profile
| Research Interests
| Selected Publications
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Profile
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1980
1980-1981
1981-1982
1982-1984
1984-1995
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Ph.D.,
York University
Postdoctoral Fellow,
York University,
Postdoctoral Fellow,
Sick Children Hospital, University of
Toronto
Postdoctoral Fellow, University
of Washington
Assistant, Associate,
and Full Professor,
Institute of
Biological Chemistry, Washington State
University
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Research Interests
Flower Development in rice
Flowering
plants complete their life cycle by shifting from
vegetative to reproductive growth. In order to understand
the early stage development of the reproductive
organs, we have been working on regulatory genes
that may be involved in controlling flower or fruit
formation.
It has been well established that
a group of regulatory genes controls flower development.
In order to understand roles of these regulatory
genes in monocot plants, we have been studying the
MADS box genes from rice. We have shown that there
are a group of MADS box genes that are involved
in controlling flowering time and organ development.
Ectopic expression of several MADS box genes resulted
in early flowering, suggesting that some MADS box
genes are involved in controlling flowering time.
In addition, these MADS box genes pay an important
role in organ developmetn. For example, the leafy
hull (lhs) mutant that is defective in
palea and lemma development is due point mutations
within the MADS box of OsMADS1.
T-DNA tagging of rice genome
There
has been much progress in the development of strategies
to discover the function of plant genes. The development
of the strategies has been largely based on genetic
approaches such as mutant identification and map-based
gene isolation. Gene inactivation by insertion of
a transposon has been employed for functional studies
in several plant species. The use of T-DNA as a
mutagen has also been developed for tagging genes
in Arabidopsis. It is believed that T-DNA insertion
is a random event, and that the inserted genes are
stable through multiple generations. We have generated
over 30,000 T-DNA tagged lines of rice. The binary
vector used in the insertion contained the promoterless
gus reporter gene, allowing detection of
a gene fusion between gus and an endogenous
gene, which is tagged by T-DNA. The data revealed
that at least 5% of the lines are GUS positive.
The large population of T-DNA tagged lines is used
for identifying insertional mutants in various genes
and for discovering new genes in rice.
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Selected Publications
Jeon J-S, Jang S, Lee S, Nam J,
Kim C, Lee S-H, Chung Y-Y, Kim S-R, Lee YH, Cho
Y-G, An G, "leafJeon J-S, Jang S, Lee S, Nam J, Kim C, Lee S-H, Chung Y-Y, Kim S-R, Lee YH, Cho Y-G, An G. 2000. leafy hull sterile (lhs1) is a homeotic mutation in a rice MADS box gene affecting rice flower development. Plant Cell 12 (6): 871-884.
Sasaki A, Itoh H, Gomi K, Ueguchi-Tanaka M, Ishiyama K, Kobayashi M, Jeong D-H, An G, Kitano H, Ashikari M, Matsuoka M. 2003. Accumulation of phosphorylated repressor for gibberellin signaling in an F-box mutant. Science 299: 1896-1898.
An S, Park S, Jeong D-H, Lee D-Y, ...... An G. 2003. Generation and analysis of end-sequence database for T-DNA tagging lines in rice. Plant Physiol 133: 2040-2047
Lee S, Kim J, Han J-J, Han M-J, An G. 2004. Functional analyses of the flowering time gene OsMADS50, the putative SUPPRESSOR OF OVEREXPRESSION OF CO 1/AGAMOUS-LIKE 20 (SOC1/AGL20) ortholog in rice. Plant J 38: 754-764
An G, Lee S, Kim S-H, Kim S-R. 2005. Molecular genetics using T-DNA in rice. Plant and Cell Physiology 14: 14-22
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Division
of Molecular & Life Sciences| POSTECH |
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