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Profile
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1967
1970-1993
1981
1993-1995
1994-1996
1996-1998
1999-2001
2003-
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Ph.D. Univ. of North
Carolina at Chapel Hill (Biochemistry)
Asst. Prof., Assoc. Prof., Full Prof.Dept.
of Biochemistry, Univ. of North Carolina
at Chapel Hill, USA
Visiting Prof.
Institut de Biochemie, Univ. Louis Pasteur
Strasbourg, France
Adjunct Prof.Dept.
of Biochemistry, Univ. of North Carolina
at Chapel Hill
Director Biotechnology
Res. Center, POSTECH
Vice-President,
POSTECH
Head, Dept, of Life Science
Director,
Postech Biotech Center
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 TOP
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Research Interests
1. Tumor growth and metastasis
through angiogenesis
Tumor cells secret the
hormones that stimulate endothelial cells for the
formation of new blood vessels from the pre-existing
vessels (angiogenesis). Tumor cells receive oxygen
and nuturiants through the vessels. During angiogenesis
the neighboring extracellular matrix is destroyed
and this process also promotes metastasis of tumor
cells. We have discovered several short peptides
that inhibit the angiogenesis induced by tumor cells
from peptide libraries. One class binds to angiogenin
with high specificity and other to vascular endothelial
growth factor (VEGF). These peptides inhibit tumor
growth and metastasis. We also discovered that beta-amyloid
interacts with angiogenic factors. We are investigating
if this has any relevance to the damage of brain
blood vessels in Alzheimer disease.
2. Autoimmune antibodies responsible
for hyperthyroidism(Graves' disease)
In patients
with Graves' disease, autoimmune antibodies stimulate
the receptor of thyroid stimulating hormone (TSH
or thyrotropin). This causes continuous production
of thyroid hormones T3 and T4 that are involved
in regulation of metabolism. In each patient, there
appears to be several clones of the stimulating
antibodies (TSAb) that interact with the receptor,
and the antibodies appear to recognize conformational
epitopes. We are in the process of identifing the
peptides that interact with different TSAb clones
and prevent the action of TSAb. These peptides will
be used for development of immunosuppressive drugs,
diagnosis and classification of different TSAb clones
and prognosis of Graves' disease.
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Selected Publications
Park, J.Y., Kim, I.J., Lee, M.H.,
Seo, J.K., Suh, P.-G., Cho, B.Y., Ryu, S.H. and
Chae, C.-B. (1997) Identification of the peptides
that inhibit the stimulation of TSH receptor by
Graves' autoimmune antibodies from peptide libraries.
Endocrinlogy 138:617-626.
Gho, Y.S. and Chae, C-B. (1997)
Development of anti-angiogenic peptides using hydropathic
complementary approach. J. Biol. Chem. 272:24294-24299
Cho, J.H., Ha, S.J., Kao, L.R.,
Megraw, T.L., and Chae, C.-B.(1998) A novel DNA-binding
protein bound to the mitochondrial inner membrane
restores the null mutation of mitochondrial histone
Abf2p in Saccharomyces cerevisiae. Mol. Cell. Biol.18:5712-5723
Lee, M.H., Park, J.Y., Cho, B.Y.
and Chae, C.-B. (1999) Expression of the functional
extracellular domain of human thyrotropin receptor
using vaccinia virus system. J. Clinical Endocrinol.
& Metab. 84: 1391-1397
Bae, D.G., Gho, Y.S. and Chae, C.-B.
(2000) Arginine-rich anti-VEGF peptides that inhibit
tumor growth and metastasis. J. Biol. Chem. 275:13588-13596
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