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Choi, Kwan Yong, Ph.D.
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Professor Department of Life Science Division
of Molecular and Life Sciences Protein
Chemistry and Protein Engineering
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Publications
Abstract E-mail kchoi@postech.ac.kr Phone +82-54-279-2295(office) +82-54-279-5977(lab.) Laboratory System Protein Biochemistry lab.
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Profile
| Research Interests
| Selected Publications
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Profile
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1988 1977-1982 1982-1987 1988-1989
1989-1990
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Ph.D.,
University of California, Davis, CA Senior
Researcher, Korea Research Institute
of Standards and Sciences Post Graduate
Researcher, University of California,
Davis, CA Post Doctoral Fellow, Medical
School University of California, Davis,
CA National Research Council Research
Associate National Institute of Health
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TOP
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Research Interests
Protein Engineering Our
primary research interest is to understand mechanistic
actions and roles of proteins which are important
in the biological system by use of protein engineering. We
have been focusing on the studies of viral proteins,
proteases, enzymes converting steroids, enzymes
in signal transduction and proteins for environmental
applications. Our approach includes biochemical,
molecular biological and biophysical methods based
on genetic engineering techniques to elucidate the
structure-function relationship of the protein at
the molecular level. Currently major efforts are
exerted on viral proteases from potyviruses, carboxypeptidase
A, ketosteroid isomerases and inositol trisphosphate
3-kinase. We are also interested in developing novel
inhibitors of the enzymes and useful expression
systems for the application of our research works
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Selected Publications
- Cha HJ, Kim J, Hong SM, Hong SJ, Park JH,
Kim ES, Wang HJ, Choi YJ, Do IG, Joh JW, Kim
DS, Choi KY
Overexpression of renal tumor
antigen is associated with tumor invasion and
poor prognosis of hepatocellular carcinoma ANN
SURG ONCOL 2011 In press
- Kim ES, Kim CO, Park JW, Choi KY
Detection
of central single-nucleotide mismatches in short
duplex DNAs on hyper-branched amine surfaces BioChip
J. 2011 5(2):137-144
- Kim ES, Hong BJ, Park CW, Kim Y, Park JW,
Choi KY
Effects of lateral spacing on enzymatic
on-chip DNA polymerization. Biosensors and
Bioelectronics 2011 26:2566-2573
- Hong BH, Oh SJ, Hong BJ, Jang DS, Yun YS,
Park JW, Choi KY
Oligonucleotide microarrays
with high discriminating power for the detection
of single nucleotide variations in the p53 gene. Mol
Cells 2010 30(6):575-579
- Yoon JH, Kim ES, Lee SJ, Park CW, Cha HJ,
Hong BH, Choi KY
Apoptosis-related mRNA expression
profiles of ovarian cancer cell lines following
cisplatin treatment. J Gynecol Oncol 2010
21(4):255-261
- Kwon JH, Kim J, Park JY, Hong SM, Park CW,
Hong SJ, Park SY, Choi YJ, Do I, Joh JW, Kim
DS, Choi KY
Overexpression of HMGB2 is associated
with tumor aggressiveness and prognosis of hepatocellular
carcinoma. Clin Cancer Res. 2010 16(22):5511-5521
- Park SH, Doh J, Park SI, Lim JY, Kim SM,
Youn JI, Jin HT, Seo SH, Song MY, Sung SY, Kim
M, Hwang SJ, Choi JM, Lee SK, Lee HY, Lim CL,
Chung YJ, Yang D, Kim HN, Lee ZH, Choi KY, Jeun
SS, Sung YC
Branched oligomerization of cell-permeable
peptides markedly enhances the transduction
efficiency of adenovirus into mesenchymal stem
cells. Gene Ther. 2010 17(8):1052-61
- Yang SY, Yang JA, Kim ES, Jeon G, Oh EJ,
Choi KY, Hahn SK, Kim JK
Single-file diffusion
of protein drugs through cylindrical nanochannels. ACS
Nano. 2010 27;4(7):3817-22
- Kim J, Hong SJ, Park JY, Park JH, Yu YS,
Park SY, Lim EK, Choi KY, Lee EK, Paik SS, Lee
KG, Wang HJ, Do IG, Joh JW, Kim DS
Epithelial-mesenchymal
transition gene signature to predict clinical
outcome of hepatocellular carcinoma. Cancer
Sci. 2010 101(6):1521-8
- Lee D, Kwon JH, Kim EH, Kim ES, Choi KY
HMGB2
stabilizes p53 by interfering with E6/E6AP-mediated
p53 degradation in human papillomavirus-positive
HeLa cells. Cancer Letters 2010 292(1):125-32
- Hong SJ, Kim J, Park JH, Lim EK, Kim J,
Choi YJ, Gu HD, Kim SW, Choi KY, Joh JW, Kim
DS
Proteomic Profiling of Human Hepatocellular
Carcinoma Tissues by Two-Dimensional Electrophoresis
and Mass Spectrometry. Biochip Journal 2009
3(3):237-248
- Lee D, Park CW, Paik SR, Choi KY
The
modification of alpha-synuclein by dicarbonyl
compounds inhibits its fibril-forming process. Biochin
Biophys Acta. 2009 1794(3):421-430
- Yoo HJ, Yun BR, Kwon JH, Ahn HS, Seol MA,
Lee MJ, Yu GR, Yu HC, Hong B, Choi K, Kim DG
Genetic
and expression alterations in association with
the sarcomatous change of cholangiocarcinoma
cells. Exp Mol Med. 2009 28;41(2):102-15
- Kim TG, Cha HJ, Lee HJ, Heo SD, Choi KY,
Ku JK, Ban C.
Structural insights of the
nucleotide dependent conformational changes
of Thermotoga maritima MutL using small-angle
X-ray scattering analysis. J Biochem. 2009
145(2):199-206
- Lee HJ, Jang do S, Cha HJ, Moon HS, Hong
BH, Choi KY, Lee HC.
NMR studies on the equilibrium
unfolding of ketosteroid isomerase by urea. J
Biochem. 2008 144(2):215-21
- Lee HJ, Yoon YJ, Jang do S, Kim C, Cha HJ,
Hong BH, Choi KY, Lee HC.
15N NMR relaxation
studies of Y14F mutant of ketosteroid isomerase:
the influence of mutation on backbone mobility. J
Biochem. 2008 144(2):159-66
- Lee HJ, Moon HS, Jang do S, Cha HJ, Hong
BH, Choi KY and Lee HC
Probing the equilibrium
unfolding of ketosteroid isomerase through xenon-perturbed(1)H-15N
multidimensional NMR spectroscopy J Biomol
NMR. 2008 40(1):65-70
- Seong Kyu Song, Zina Moldoveanu, Huan H.
Nguyen, Eui-Ho Kim, Kwan Yong Choi, Jong Bae
Kim and Jiri Mestecky
Intranasal immunization
with influenza virus and Korean mistletoe lectin
C (KML-C) induces heterosubtypic immunity in
mice Vaccine 2007 25(34):6359-6366
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Division
of Molecular & Life Sciences| POSTECH |
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