Choi, Kwan Yong, Ph.D.

Professor
Department of Life Science
Division of Molecular and Life Sciences
Protein Chemistry and Protein Engineering

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Publications Abstract
E-mail kchoi@postech.ac.kr
Phone +82-54-279-2295(office)
          +82-54-279-5977(lab.)
Laboratory System Protein Biochemistry lab.

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Profile |  Research Interests |  Selected Publications

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1988
1977-1982
1982-1987
1988-1989
1989-1990

Ph.D., University of California, Davis, CA
Senior Researcher, Korea Research Institute of Standards and Sciences
Post Graduate Researcher, University of California, Davis, CA
Post Doctoral Fellow, Medical School University of California, Davis, CA
National Research Council Research Associate National Institute of Health

 

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Protein Engineering
Our primary research interest is to understand mechanistic actions and roles of proteins which are important in the biological system by use of protein engineering.
We have been focusing on the studies of viral proteins, proteases, enzymes converting steroids, enzymes in signal transduction and proteins for environmental applications. Our approach includes biochemical, molecular biological and biophysical methods based on genetic engineering techniques to elucidate the structure-function relationship of the protein at the molecular level. Currently major efforts are exerted on viral proteases from potyviruses, carboxypeptidase A, ketosteroid isomerases and inositol trisphosphate 3-kinase. We are also interested in developing novel inhibitors of the enzymes and useful expression systems for the application of our research works

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  1. Cha HJ, Kim J, Hong SM, Hong SJ, Park JH, Kim ES, Wang HJ, Choi YJ, Do IG, Joh JW, Kim DS, Choi KY
    Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma
    ANN SURG ONCOL 2011 In press
  2. Kim ES, Kim CO, Park JW, Choi KY
    Detection of central single-nucleotide mismatches in short duplex DNAs on hyper-branched amine surfaces
    BioChip J. 2011 5(2):137-144
  3. Kim ES, Hong BJ, Park CW, Kim Y, Park JW, Choi KY
    Effects of lateral spacing on enzymatic on-chip DNA polymerization.
    Biosensors and Bioelectronics 2011 26:2566-2573  
  4. Hong BH, Oh SJ, Hong BJ, Jang DS, Yun YS, Park JW, Choi KY
    Oligonucleotide microarrays with high discriminating power for the detection of single nucleotide variations in the p53 gene.
    Mol Cells 2010 30(6):575-579   
  5. Yoon JH, Kim ES, Lee SJ, Park CW, Cha HJ, Hong BH, Choi KY
    Apoptosis-related mRNA expression profiles of ovarian cancer cell lines following cisplatin treatment.
    J Gynecol Oncol 2010 21(4):255-261  
  6. Kwon JH, Kim J, Park JY, Hong SM, Park CW, Hong SJ, Park SY, Choi YJ, Do I, Joh JW, Kim DS, Choi KY
    Overexpression of HMGB2 is associated with tumor aggressiveness and prognosis of hepatocellular carcinoma.
    Clin Cancer Res. 2010 16(22):5511-5521  
  7. Park SH, Doh J, Park SI, Lim JY, Kim SM, Youn JI, Jin HT, Seo SH, Song MY, Sung SY, Kim M, Hwang SJ, Choi JM, Lee SK, Lee HY, Lim CL, Chung YJ, Yang D, Kim HN, Lee ZH, Choi KY, Jeun SS, Sung YC
    Branched oligomerization of cell-permeable peptides markedly enhances the transduction efficiency of adenovirus into mesenchymal stem cells.
    Gene Ther. 2010 17(8):1052-61  
  8. Yang SY, Yang JA, Kim ES, Jeon G, Oh EJ, Choi KY, Hahn SK, Kim JK
    Single-file diffusion of protein drugs through cylindrical nanochannels.
    ACS Nano. 2010 27;4(7):3817-22  
  9. Kim J, Hong SJ, Park JY, Park JH, Yu YS, Park SY, Lim EK, Choi KY, Lee EK, Paik SS, Lee KG, Wang HJ, Do IG, Joh JW, Kim DS
    Epithelial-mesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma.
    Cancer Sci. 2010 101(6):1521-8   
  10. Lee D, Kwon JH, Kim EH, Kim ES, Choi KY
    HMGB2 stabilizes p53 by interfering with E6/E6AP-mediated p53 degradation in human papillomavirus-positive HeLa cells.
    Cancer Letters 2010 292(1):125-32  
  11. Hong SJ, Kim J, Park JH, Lim EK, Kim J, Choi YJ, Gu HD, Kim SW, Choi KY, Joh JW, Kim DS
    Proteomic Profiling of Human Hepatocellular Carcinoma Tissues by Two-Dimensional Electrophoresis and Mass Spectrometry.
    Biochip Journal 2009 3(3):237-248
  12. Lee D, Park CW, Paik SR, Choi KY
    The modification of alpha-synuclein by dicarbonyl compounds inhibits its fibril-forming process.
    Biochin Biophys Acta. 2009 1794(3):421-430
  13. Yoo HJ, Yun BR, Kwon JH, Ahn HS, Seol MA, Lee MJ, Yu GR, Yu HC, Hong B, Choi K, Kim DG
    Genetic and expression alterations in association with the sarcomatous change of cholangiocarcinoma cells.
    Exp Mol Med. 2009 28;41(2):102-15
  14. Kim TG, Cha HJ, Lee HJ, Heo SD, Choi KY, Ku JK, Ban C.
    Structural insights of the nucleotide dependent conformational changes of Thermotoga maritima MutL using small-angle X-ray scattering analysis.
    J Biochem. 2009 145(2):199-206
  15. Lee HJ, Jang do S, Cha HJ, Moon HS, Hong BH, Choi KY, Lee HC.
    NMR studies on the equilibrium unfolding of ketosteroid isomerase by urea.
    J Biochem. 2008 144(2):215-21
  16. Lee HJ, Yoon YJ, Jang do S, Kim C, Cha HJ, Hong BH, Choi KY, Lee HC.
    15N NMR relaxation studies of Y14F mutant of ketosteroid isomerase: the influence of mutation on backbone mobility.
    J Biochem. 2008 144(2):159-66  
  17. Lee HJ, Moon HS, Jang do S, Cha HJ, Hong BH, Choi KY and Lee HC
    Probing the equilibrium unfolding of ketosteroid isomerase through xenon-perturbed(1)H-15N multidimensional NMR spectroscopy
    J Biomol NMR. 2008 40(1):65-70
  18. Seong Kyu Song, Zina Moldoveanu, Huan H. Nguyen, Eui-Ho Kim, Kwan Yong Choi, Jong Bae Kim and Jiri Mestecky
    Intranasal immunization with influenza virus and Korean mistletoe lectin C (KML-C) induces heterosubtypic immunity in mice
    Vaccine 2007 25(34):6359-6366

 

 

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Division of Molecular & Life Sciences| POSTECH