Cho, Yunje, Ph.D.

Professor
Department of Life Science
Division of Molecular and Life Sciences
Cancer Biology, Structural Biology

Publications Abstract
E-mail yunje@postech.ac.kr
Phone +82-54-279-2288(office)
          +82-54-279-8063(lab.)
Laboratory  Structural Biology of Cancer

Profile |  Research Interests |  Selected Publications

Profile

Research Interests

Structural Cancer biology
Our research group is interested in obtaining structural information of proteins involved in the control of cell growth and proliferation.  Since alterations of the proteins involved these pathway could cause cancer, understanding of the structure  function of these proteins could provide information (i) to understand the molecular basis of tumor formation and inhibition, and (ii) to approach rational method to design novel anti-cancer drugs.  We are currently focused on structural studies on Retinoblastoma tumor suppressor-viral oncoprotein complex, BRCA1 and BRCA2 (Breast Cancer Susceptibility Gene) to elucidate their biochemical and cellular functions. Loss of tumor suppressor function of these proteins cause diverse types of cancers including breast and ovary cancer

Structural Genomics on Cancer initiative
We are also working on the Structural Genomics project in collaboration with several other groups (University of California, Berkeley and KIST).  Our Goal is to identify the molecular and cellular function of several proteins involved in DNA repair, cell cycle regulation and other metabolic pathways based on the structural information. Such information would allow us to design anti-biotics anti-cancer drugs by rational drug design approach.  The newly built synchrotron at POSTECH will play important roles in our structural genomics project.

Selected Publications

1. Crystal structure of the Mre11-Rad50-ATP{gamma}S Complex: understanding the interplay between Mre11 and Rad50
   Lim HS, Kim JS, Park YB, Gwon GH, Cho Y.   Genes Dev (2011) 25(10) : 1091-104
   
2. DDS, 4,4′-diaminodiphenylsulfone, extends organismic lifespan
   Sung Chun Choa, Moon Cheol Park, Bhumsuk Keamd, Jung Min Choie, Yunje Choe, Soonsil Hyunf, Sang Chul Parka, and Junho Leec Proc. Natl. Acad. Sci. U. S. A. (2010) 107(45) : 19326-19331
3. The hsSsu72 phosphatase is a cohesin-binding protein that regulates the resolution of sister chromatid arm cohesion
   HS Kim, KH Baek, GH Ha, JC Lee, YN Kim, Janet Lee, HY Park, NR Lee, Ho Lee, Y Cho and CW Lee
   EMBO JOURNAL (2010) 29(20) : 3544-3557
4. Structure of the Cdt1 C-terminal domain: conservation of the winged helix fold in replication licensing factors.
   BI. Khayrutdinov, WJ Bae, YM Yun, JH Lee, Takashi Tsuyama, JJ Kim, Eunha Hwang, KS Ryu, HK Cheong, CJ Cheong, JS Ko, Takemi Enomoto, P. Andrew Karplus, Peter Guntert, Shusuke Tada, YH Jeon and Y Cho 
   PROTEIN SCIENCE (2009) 18(11) : 2252-64
5. Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.
   Jeong HW, Jeon US, Koo BK, Kim WY, Im SK, Shin Juhee, Cho Yunje, Kim Jin, Kong YY.  J CLIN INVEST (2009) 119(11) : 3290-3300
6. Label-free electrochemical detection of the p53 core domain protein on its antibody immobilized electrode.
   Yeo J, Park JY, Bae WJ, Lee YS, Kim BH, Cho Y, Park SM. Anal Chem(2009) 81(12):4770-7
7. Repair activities of human 8-oxoguanine DNA glycosylase are stimulated by the interaction with human
   Tsuyama T, Watanabe S, Aoki A, Cho Y, Seki M, Enomoto T, Tada S.  Mol Biol Cell(2009) 20(3):937-47
8. Crystal stucture of the human rad9-hus1-rad1 clamp
   Sohn SY, Cho Y.   J Mol Biol (2009) 390 : 490-502
   
9. Crystal structure of the eIF4A-PDCD4 complex
   J. H. Chang,  Y. H. Cho,  S. Y. Sohn,  J. M. Choi,  A. Kim,  S. K. Jang and Y. Cho   Proc Natl Acad Sci USA  (2009) 106 : 3148-3153
10. Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the central zinc-binding domain of the human Mcm10 DNA-replication factor
    N. Y. Jung,  W. J. Bae,  J. H. Chang,  Y. C. Kim and Y. Cho  Acta Cryst. F Struct. Biol. Cryst. Commun. (2008) 64(Pt 6) : 495-7
11. Crystal structure of the Mus81-Eme1 complex
    J. H. Chang,  J. J. Kim,  J. M. Choi,  J. H. Lee and Y. Cho  Genes & Dev. (2008) 22: 1093-1106
12. Crystal structure of human DGCR8 core
    S. Y. Sohn,  W. J. Bae,  J. J. Kim,  K. H. Yeom, V. N. Kim and Y. Cho   Nat. Struct. Mol. Biol. (2007) 14(9):847-53
13. Crystal structure of human GINS complex
    J. M. Choi,  H. S. Lim,  J. J. Kim, O. K. Song, and Y. Cho   Genes & Dev. (2007)
14. Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein
    J. M. Choi,  S. Y. Kang, W. J. Bae, K. S. Jin, M. Ree, Y. Cho    J.Biol.Chem (2007) 282:9941-51

Division of Molecular & Life Sciences| POSTECH