Sung Key Jang, Ph.D.

Professor
Department of Life Science
Division of Molecular and Life Sciences
Molecular Virology

bar04_solid1x1_gray.gif

Publications Abstract
E-mail sungkey@postech.ac.kr
Phone +82-54-279-2298(office)
          +82-54-279-5985(lab.)
Laboratory Molecular Virology lab.

bar04_solid1x1_black.gif

Profile |  Research Interests  |  Selected Publications

bar04_solid1x1_black.gif

           

dia_red.gif Profile

1989
1989-1991

Ph.D., State University of New York, Stony Brook
Post-doctoral Associate, State University of New York, Stony Brook

 

black01_up.gifTOP

     

dia_red.gif Research Interests

Molecular Virology I
Cap-independent translation of eukaryotic mRNAs requires a specific RNA structure, named `internal ribosomal entry site (IRES)', in the mRNA and IRES-specific cellular factors along with basic translational machinery. We are investigating molecular mechanism of translation via IRESes by analyzing cis-acting elements and cellular factors interacting with IRESes of viral ［encephalomyocarditis virus, poliovirus and hepatitis C virus (HCV)］ and cellular (Bip, c-myc) IRESes. The roles of IRES-dependent translation in the cell cycle and differentiation process are also under investigation.
HCV is an enveloped RNA virus containing a single positive sense RNA in a virion particle. The genomic RNA encodes a polyprotein (~3010 amino acids) with the following gene order: 5'-C-E1-E2-NS2-NS3-NS4A-NS4B-NS5A-NS5B-3'. During and/or after synthesis the polyprotein is processed into functional proteins by host- and virus-encoded proteases. Core (C) and envelope proteins (E1 and E2) are believed to compose the structural elements of the virion particle. NS2, NS3, and NS4A are involved in the proteolytic processing of the HCV polyprotein. RNA-dependent RNA polymerase and RNA helicase activities are assigned to NS5B and the C-terminal two-thirds of NS3, respectively. We are investigating the biochemical properties of NS3, which contains both protease and helicase domains. We are trying to develop anti-HCV drug based on HCV protease inhibitor activity. Currently, modulation of cellular function by HCV proteins is also under investigation.

black01_up.gifTOP

      

dia_red.gif Selected Publications 
 
  1. So-Young Lee, Sung K. Jang, and Mieyoung Choi.
    Human hnRNP L shuttles between nucleus and cytoplasm.
    Kor. J. Genetics. 2003 June:25(2): 141-145.
  2. Hong-Gyu Park, Ji-Young Yoon, Sung Key Jang, and Mieyoung Choi.
    Two-hybrid cloning identifies hnRNP A/B0 as an interactive protein of hnRNP L.
    Kor. J. Genetics. 2003 Sep:25(3): 269-277.
  3. Jae Cheal Yoo, Jae Rak Chang, Sung Hwan Kim, Sung Key Jang, Debra J. Wolgemuth, Kyungjin Kim, and Kunsoo Rhee.
    NIP1/XB51/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi.
    Experimental Cell Res. 2004 Feb:292(2): 393-402.
  4. Kobong Choi, Jong Heon Kim, Xiaoyu Li, Ki Young Paek, Sang Hoon Ha, Sung Ho Ryu, Ecard Wimmer, and Sung Key Jang.
    Identification of Cellular Proteins Enhancing Activities of Internal Ribosomal Entry Sites by Competition with Oligodeoxynucleotides.
    Nucleic Acids Res. 2004 Feb:32(4): 1308-1317.
  5. Jung M. Choi, Eun Y. Park, Jun H. Kim, Sung K. Jang, and Yunje Cho.
    Probing the Functional Importance of the Hexameric Ring Structure of RNase PH.
    J. Biol. Chem. 2004 Jan:279(1): 755-764.
  6. Jong H. Kim, Ki Y. Paek, Sang H. Ha, Sungchan Cho, Kobong Choi, Sung H. Ryu and Sung K. Jang.
    A cellular RNA-binding protein enhances Internal Ribosomal Entry Site-dependent translation through an interaction downstream of the hepatitis C viral polyprotein initiation codon.
    Mol. Cell. Biol. 2004 Sep:24(18): 7878-7890.
  7. Byounghoon Hwang, Jung S. Cho, Hyeon Ju Yeo. Ung-H. Kim, Kyung M. Chung, Kyungsook Han, Sung K. Jang, and Seong-Wook Lee.
    Isolation of specific and high-affinity RNA aptamers against NS3 helicase domain of hepatitis C virus.
    RNA. 2004 Aug:10(8): 1277-1290.
  8. Woo Jae Kim, Sung Hoon Back, Vit Kim, Incheol Ryu and Sung Key Jang.
    Sequestration of TRAF2 into stress granules interrupts Tumor Necrosis Factor  signaling under stress conditions.
    Mol. Cell. Biol. 2005 Mar:25(6): 2450-2462.
  9. Sungchan Cho, Jong Heon Kim, Sung Hoon Back, and Sung Key Jang.
    Polypyrimidine Tract-Binding Protein Enhances the Internal Ribosomal Entry Site-Dependent Translation of p27Kip1 mRNA and Modulates Transition from G1 to S Phase.
    Mol. Cell. Biol. 2005 Feb:25(4): 1283-1297.
  10. Tae-Don Kim, Jong-So Kim, Jong Heon Kim, Jihwan Myung, Hee Don Chae, Kyung-Chul Woo, Sung Key Jang, Duk-Su Koh, and Kyong-Tae Kim.
    Rhythmic serotonin N-acetyltransferase mRNA degradation is essential for the maintenance of its circadian oscillation.
    Mol. Cell. Biol. 2005 Apr:25(8): 3232-3246.
  11. Chengyu Liang, Elizabeth Rieder, Bumsuk Hahm, Sung Key Jang, Aniko Paul, Eckard Wimmer.
    Replication of a Novel Subgenomic HCV Genotype 1a Replicon Expressing a Puromycin Resistance Gene in Huh-7 Cells.
    Virology. 2005 Mar:333(1): 41-53.
  12. Song H. Lee, Yoon K. Kim, Chon S. Kim, Su K. Seol, Jonnhyun Kim, Sungchan Cho, Young L. Song, Ralf Bartenschlager, and Sung Key Jang.
    E2 of Hepatitis C virus inhibits apoptosis.
    J. Immunology. 2005 Dec:175(12): 8226-8235.
  13. Ju Yeop Shin, Wonhee Hur, Jin Sang Wang, Jeong Won Jang, Chang Wook Kim, Si Hyun Bae, Sung Key Jang, Se-Hwan Yang, Young Chul Sung, Oh-Joo Kwon and Seung Kew Yoon.
    HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-β1.
    Exp. Mol. Med. 2005 Apr:37(2): 138-145.
  14. Sung Key Jang.
    Internal initiation: IRES elements of picornaviruses and hepatitis c virus.
    Virus Res. 2006 Jul:119(1): 2-15.
  15. Seung Y. Yang, Incheol Ryu, Hwang Y. Kim, Jin K. Kim,Sung K. Jang, and Thomas P. Russell.
    Nanoporous Membranes with Ultrahigh Selectivity and Flux for the Filtration of Viruses.
    Adv. Mater. 2006 Mar:18(6): 709-712.
  16. Byul Nae Yoo, Hae Ok Kim, Hyung Ryong Moon, Su Kyoung Seol, Sung Key Jang, Kang Man Lee and Lak Shin Jeong.
    Synthesis of 2-C-hydroxymethylribofuranosylpurines as potent anti-hepatitis C virus (HCV) agents.
    Bio. & Med. Chem. Letters. 2006 Aug:16(16):4190-4164.
  17. Ha SH, Kim DH, Kim IS, Kim JH, Lee MN, Lee HJ, Kim JH, Jang SK, Suh PG, Ryu SH.
    PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals.
    Cell Signal. 2006 Dec:18(12):2283-2291.
  18. Seo YJ, Jeong HS, Bang EK, Hwang GT, Jung JH, Jang SK, Kim BH.
    Cholesterol-linked fluorescent molecular beacons with enhanced cell permeability.
    Bioconjug. Chem. 2006 Dec:17(5): 1151-1155.
  19. Sungchan Cho, Sung Mi Park, Tae Don Kim, Jong Heon Kim, Kyong-Tai Kim, and Sung Key Jang.
    BiP Internal Ribosomal Entry Site Activity Is Controlled by Heat-Induced Interaction of NSAP1.
    Mol. Cell. Biol. 2007 Jan:27(1): 368-383.
  20. Chon Saeng Kim, Su Kyoung Seol, Ok-Kyu Song, Ji Hoon Park, and Sung Key Jang.
    An RNA-binding protein hnRNP A1 and a scaffold protein septin 6 facilitate Hepatitis C Virus replication.
    J. Virology. 2007 Apr: 81(8): 3852-3865.

 

 

black01_up.gifTOP

 

bar04_solid1x1_gray.gif

Division of Molecular & Life Sciences| POSTECH