Sanguk Kim, Ph.D.

Associate Professor
Department of Life Science
Division of Molecular and Life Sciences
Bioinformatics

E-mail sukim@postech.ac.kr
Phone +82-54-279-2348(office)
          +82-54-279-8171(lab.)
Laboratory Structural Bioinformatics Laboratory

Profile |  Research Interests |  Selected Publications

Profile

Research Interests

Computational structural biology and bioinformatics - Structural and functional characterization of membrane proteins - Development of prediction methods for protein structure and protein-protein interaction Structural Bioinformatics of Membrane Proteins Membrane proteins serve many important cellular functions including cell-cell communications, signal transductions, and ion/nutrient transportations. Defects in membrane proteins are related to the diseases in cancer, heart diseases, immunological and neurological disorders. Thus, improving our understanding of membrane protein structure and function should have a significant impact on medicine. In spite of their importance, our understanding of membrane protein is limited due to the difficulties in current methods of structural biology. Thus, effective structure prediction methods combined with designed biophysical and biochemical experiments should have an enormous impact on our understanding of membrane protein structure and function. Keywords from research publications Channel architecture, open-close & ion transport mechanism, functional & structural motif, drug binding, cell surface receptor, transmembrane cell signaling, GPCR, receptor tyrosine kinase, integrin, cell adhesion molecules, Alzheimer amyloid pore, glycine zipper, mechanosensitive channel, and tight junction protein   

Selected Publications

• Lee, D.W. Kim, J.K. Lee, S. Choi, S. Kim, S.* Hwang, I.* (2008). “Nuclear-encoded plastid transit peptides contain multiple sequence subgroups with distinctive chloroplast-targeting sequence motifs.” Plant Cell In press. *Corresponding authors
• Kim, Y.Y. Kim, D.Y. Shim, D. Song, W.Y. Lee, J. Schroeder, J.I. Kim, S. Moran, N. Lee, Y. (2008). “Expression of the novel wheat gene TM20 confers enhanced cadmium tolerance to baker’s yeast.” J. Biol. Chem. 283(23):15893-15902.
• Kim, H.R. Lee, G.H. Ha, K.C. Ahn, T. Lee, B.J. Choo, S.G. Kim, S. Seo, Y.R. Shin, Y.J. Chae, S.W. Reed, J.C. Chae, H.J. (2008). “Bax inhibitor-1 (BI-1) is a pH-dependent regulator of Ca2+ channel activity in the endoplasmic reticulum.” J. Biol. Chem. 283(23):15946-15955.
• Page, R.C. Kim, S. Cross, T.A. (2008). “Transmembrane helix uniformity examined by spectral mapping of torsion angles.” Structure 16: 787-797.
• Gorman, P.M. Kim, S. Guo, M. Melnyk, R. McLaurin, J. Fraser, P.E. Bowie, J. Chakrabartty, A. (2008). “Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer’s disease mutants.” BMC Neuroscience 9, 1-11.
• Choi, S. Jeon, J. Yang, J.S. Kim, S. (2008). “Common occurrence of internal repeat symmetry in membrane proteins.” Proteins 71, 68-80.
• Plotkowski, M.L. Kim, S. Phillips, M.L. Partridge, A.W. Deber, C.M. Bowie, J.U. (2007). “The transmembrane domain of Myelin Protein Zero can form dimers: Possible implications for Myelin construction.” Biochemistry 46, 12164-12173.
• Kim, Y.K. Park, H.W. Yang, J.S. Oh, S.Y. Chang Y.S, Shin, E.S. Lee, J.E. Kim, S.* Gho Y.S. Cho, S.H. Min, K.U. Kim, Y.Y. (2007). “Association and functional relevance of E237G, a polymorphism of the high-affinity IgE-receptor beta chain gene, to airway hyperresponsiveness.” Clin Exp Allergy 37, 592-598.
• Barwe, S.P.* Kim, S.* Rajasekaran, S.A. Bowie, J.U. Rajasekaran, A.K. (2007). “Janus model of the Na,K-ATPase β-subunit transmembrane domain: Distinct faces mediate α/β assembly and β-β homo-oligomerization.” J. Mol. Biol. 365, 706-714.
• Jeong, M.Y.* Kim, S.* Yun, C.W. Choi, Y.J. Cho, S.G. (2007). “Engineering a de novo internal disulfide disulfide bridge to improve the thermal stability of xylanase from Bacillus stearothermophilus No. 236.” J. Biotechnol.127, 300-309. 

Division of Molecular & Life Sciences| POSTECH