Kim, Yoon-Keun, M.D., Ph.D.

Professor
Department of Life Science
Division of Molecular and Life Sciences
Allergy & Immunology

Profile |  Research Interests  |  Selected Publications

Profile

Research Interests

1. Basic Research to establish new paradigm of pathogenesis of
   immune-based inflammatory diseases
   1) Target diseases
        (1) Respiratory system
             - Chronic obstructive airway diseases (asthma and COPD)
             - Bacterial pneumonia & Lung cancer
        (2) Skin: Atopic dermatitis
        (3) Gastrointestinal system
             - Gastritis & Peptic ulcer, & Inflammatory bowel diseases
             -  Stomach & Colorectal cancers
        (4) Cardiovascular system
             - Atherosclerosis & Thromboembolism
             - Sepsis, Diabetes, & Obesity
   2) Determine novel causative agents of inflammatory diseases and cancers, especially     focused on bacteria-derived extracellular vesicles
   3) Characterize host responses on the pathogenesis of immune-based inflammatory
       diseases
   
    
2. Translational Research to develop technologies for the Control of Immune-based Inflammatory diseases
   1) Diagnostics: develop novel biomarkers to diagnose inflammatory diseases and     cancers
   2) Preventive measures
       - Develop preventive device and foods for the prevention of inflammatory diseases
          and cancer in lung and GT tract.
       - Develop vaccines for the prevention of bacterial infections and of inflammatory
          diseases caused by bacteria-derived vesicles
   3) Therapeutics
       - Therapeutic vaccines for the treatment of inflammatory diseases
       - Highly targeted drug delivery system
       - Novel anti-inflammatory & anti-cancer agents
    

Selected Publications 

1. Park HW, Lee JE, Shin ES, Lee JY, Bahn JW, Oh HB, Oh SY, Cho SH, Moon HB, Min KU, Elias JA, Kim YY, Kim YK. Association between genetic variations of vascular endothelial growth factor receptor 2 and atopy in the Korean population. J Allergy Clin Immunol. 2006 Apr;117(4):774-9.
2. Bhandari V, Choo-Wing R, Chapoval SP, Lee CG, Tang C, Kim YK, Ma B, Baluk P, Lin MI, McDonald DM, Homer RJ, Sessa WC, Elias JA. Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung. Proc Natl Acad Sci U S A. 2006 Jul 18;103(29):11021-6.
3. Park HK, Oh SY, Kim TB, Bahn JW, Shin ES, Lee JE, Oh HB, Kim YK, Park T, Cho SH, Min KU, Kim YY. Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough. Thorax. 2006 Dec;61(12):1070-5.
4. Kim YK, Oh HB, Lee EY, Gho YS, Lee JE, Kim YY.  Association between a Genetic Variation of CC Chemokine Receptor-2 and Atopic Asthma. Allergy. 2007 Feb;62(2):208-9.
5. Jeon SG, Lee CG, Oh MH, Chun EY, Gho YS, Cho SH, Kim JH, Min KU, Kim YY, Kim YK, Elias JA. Recombinant Basic Fibroblast Growth Factor Inhibits the Airway Hyperresponsiveness, Mucus Production, and Lung Inflammation Induced by an Allergen Challenge. J Allergy Clin Immunol. 2007 Apr;119(4):831-7.
6. Kim YK, Park HW, Yang JS, Oh SY, Chang YS, Shin ES, Lee JE, Kim SU, Gho YS, Cho SH, Min KU, Kim YY. Association and Functional Relevance of E237G, a Polymorphism of the High-affinity IgE-Receptor Beta Chain Gene, to Airway Hyperresponsiveness. Clin Exp Allergy. 2007 Apr;37(4):592-8.
7. Kim YK, Oh SY, Jeon SG, Park HW, Lee SY, Chun EY, Bang B, Lee HS, Oh MH, Kim YS, Kim JH, Gho YS, Cho SH, Min KU, Kim YY, Zhu Z. Airway Exposure Levels of Lipopolysaccharide Determine Type 1 versus Type 2 Experimental Asthma. J Immunol. 2007 Apr 15;178(8):5375-82.
8. Kim SH, Kim YK, Park HW, Jee YK, Kim SH, Bahn JW, Chang YS, Kim SH, Ye YM, Shin ES, Lee JE, Park HS, Min KU. Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenet Genomics. 2007 Apr;17(4):295-304.
9. Lee EY, Bang JY, Park GW, Choi DS, Kang JS, Kim HJ, Park KS, Lee JO, Kim YK, Kwon KH, Kim KP, Gho YS. Global proteomic profiling of native outer membrane vesicles derived from Escherichia coli. Proteomics. 2007 Sep;7(17):3143-53.
10. Jeon SG, Oh SY, Park HK, Kim YS, Shim EJ, Lee HS, Oh MH, Bang B, Chun EY, Kim SH, Gho YS, Zhu Z, Kim YY, Kim YK. T(H)2 and T(H)1 lung inflammation induced by airway allergen sensitization with low and high doses of double-stranded RNA. J Allergy Clin Immunol. 2007 Oct;120(4):803-12.
11. Park HK, Park HW, Jeon SG, Shin ES, Gho YS, Cho SH, Kim YY, Kim YK. Distinct association of genetic variations of vascular endothelial growth factor, transforming growth factor-beta, and fibroblast growth factor receptors with atopy and airway hyperresponsiveness. Allergy. 2008 Apr;63(4):447-53.
12. Kim SH, Kim YK, Park HW, Kim SH, Kim SH, Ye YM, Min KU, Park HS. Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Respir Med. 2009 Mar;103(3):356-63
13. Jeon SG, Moon HG, Kim YS, Choi JP, Shin TS, Hong SW, Tae YM, Kim SH, Zhu Z, Gho YS, Kim YK. 15-lipoxygenase metabolites play an important role in the development of a T-helper type 1 allergic inflammation induced by double-stranded RNA. Clin Exp Allergy. 2009 Jun;39(6):908-17.
14. Kim YS, Hong SW, Choi JP, Shin TS, Moon HG, Choi EJ, Jeon SG, Oh SY, Gho YS, Zhu Z, Kim YK. Vascular endothelial growth factor is a key mediator in the development of T cell priming and its polarization to type 1 and type 17 T helper cells in the airways. J Immunol. 2009 Oct 15;183(8):5113-20.
15. Lee EY, Choi DY, Kim DK, Kim JW, Park JO, Kim S, Kim SH, Desiderio DM, Kim YK, Kim KP, Gho YS. Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of staphylococcus aureus-derived membrane vesicles. Proteomics. 2009 Dec;9(24):5425-36.
16. Moon HG, Kim YS, Choi JP, Choi DS, Yoon CM, Jeon SG, Gho YS, Kim YK. Aspirin attenuates the anti-inflammatory effects of theophylline via inhibition of cAMP production in mice with non-eosinophilic asthma. Exp Mol Med. 2010 Jan 31;42(1):47-60.
17. Park KS, Choi KH, Kim YS, Hong BS, Kim OY, Kim JH, Yoon CM, Koh GY, Kim YK, Gho YS. Outer Membrane Vesicles Derived from Escherichia coli Induce Systemic Inflammatory Response Syndrome. PLoS One. 2010 Jun 28;5(6):e11334.
18. Kim YS, Choi SJ, Choi JP, Jeon SG, Oh SY, Lee BJ, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK. IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model. Exp Mol Med 2010 Aug 31;42(8):533-46.
19. Moon HG, Tae YM, Kim YS, Gyu Jeon S, Oh SY, Song Gho Y, Zhu Z, Kim YK. Conversion of Th17-type into Th2-type inflammation by acetyl salicylic acid via the adenosine and uric acid pathway in the lung. Allergy. 2010 Sep 1;65(9):1093-103.
20. Shin TS, Kim JH, Kim YS, Jeon SG, Zhu Z, Gho YS, Kim YK. Extracellular vesicles are key intercellular mediators in the development of immune dysfunction to allergens in the airways. Allergy. 2010 Oct;65(10):1256-65.
21. Choi JP, Kim YS, Tae YM, Choi EJ, Hong BS, Jeon SG, Gho YS, Zhu Z, Kim YK. A viral PAMP double-stranded RNA induces allergen-specific Th17 cell response in the airways which is dependent on VEGF and IL-6. Allergy. 2010 Oct;65(10):1322-30.
22. Kim SD, Kim YK, Lee HY, Kim YS, Jeon SG, Baek SH, Song DK, Ryu SH, Bae YS. The Agonists of Formyl Peptide Receptors Prevent Development of Severe Sepsis after Microbial Infection. J Immunol. 2010 Oct 1;185(7):4302-10.
23. Shin TS, Lee BJ, Tae YM, Kim YS, Jeon SG, Gho YS, Choi DC, Kim YK. Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses. Exp Mol Med. 2010 Oct 31;42(10):721-30.
24. Kim YS, Choi SJ, Tae YM, Lee BJ, Jeon SG, Oh SY, Gho YS, Zhu Z, Kim YK. Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung. J Immunol. 2010 Nov 1;185(9):5648-55.
25. Hong SW, Kim MR, Lee EY, Kim JH, Kim YS, Jeon SG, Yang JM, Lee BJ, Pyun BY, Gho YS, Kim YK. Extracellular vesicles derived from Staphylococcus aureus induce atopic dermatitis-like skin inflammation. Allergy. 2011 Mar;66(3):351-9.
26. Lee BJ, Moon HG, Shin TS, Jeon SG, Lee EY, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK. Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-gamma. Exp Mol Med. 2011 Feb 7. [Epub ahead of print]

Division of Molecular & Life Sciences| POSTECH