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Young-Yun Kong, Ph.D.
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Associate Professor
Department of Life Science
Division
of Molecular and Life Sciences
Immunology
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Publications
Abstract
E-mail ykong@postech.ac.kr
Phone +82-54-279-2287(office)
+82-54-279-8188(lab.)
Laboratory Immunology.
and Disease control lab.
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Profile
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Interests | Selected
Publications
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Profile
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1996
1996-2000
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Ph.D.,Kyushu
University, Fukuoka
Postdoctoral
Fellow, Amgen/Ontario Cancer Institute,
University of Toronto
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 TOP
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Research Interests
Immunology
Research interests
in this laboratory aim at the elucidation of the
immune system in order to gain new insights into
various disorders, such as autoimmune diseases,
rheumatoid arthritis, atherosclerosis, and tumor.
Since these disorders are closely related to the
immune system, molecular and genetic approaches
provide the clues to understand the molecular basis
of the pathogenesis of these diseases. We are currently
focused on the T cell and dendritic cell communications
and the evaluation of TNF family cytokines, CD40L,
OPGL, and TRAIL. For this purpose, gene-targeting
approaches are carried out.
Breast development and cancer
We
are also working on the development of breast and
cancer. We found OPGL, a member of TNF family cytokine,
as a key regulator of osteoclast formation, lymph
node organogenesis, and early T and B cell development.
In addition, we also found that OPGL and its receptor
RANK interaction is essential for breast development
during pregnancy. Since breast cancer is originated
from mammary epithelial cells and its development
is closely related to breast development, further
analysis of breast development provides a clue to
understand the progress of breast cancer.
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Selected Publications
- Ran Song, Bon-Kyoung Koo, Ki-jun Yoon,
Mi-jeong Yoon, Kyeong won Yoo, Hyun-Taek
Kim, Hyeon-jeong Oh, Yoon-Young Kim, Jin-Kwan
Han, Cheol-Hee Kim, and Young-Yun Kong
"Neuralized-2
regulates notch ligand in cooperation with
mind bomb-1"J Biol Chem. 281(47),36391-36400
- Nam-Shik Kim, Hyun-Ju Kim, Bon-Kyoung Koo,
Min-Chul Kwon, Yunje Cho, Yoshifumi Yokota,
Josef M. Penninger,and Young-Yun Kong "Receptor
activator of NF-κB ligand regulates the proliferation
of mammary epithelial cells via Id2" Mol.
Cell. Biol. 26(3),1002-1013
- Bon-Kyoung Koo, Hyoung-Soo Lim, Ran Song,
Mi-Jeong Yoon, Ki-jun Yoon, Jin-Sook Moon, Young-Woong
Kim, Min-Chul Kwon, Kyeong-Won Yoo, Myung-Phil
Kong, Jinie Lee, Ajay B.Chitnis, Cheol-Hee Kim,
and Young-Yun Kong. “Mind-Bomb 1 is essential
for generating functional Notch Ligand to activate
Notch”
Development. 2005, July 132:3459-3470
- Bon-Kyoung Koo, Ki-jun Yoon, Kyeong-Won
Yoo, Hyoung-Soo Lim, Ran Song, Ju-Hoon So, Cheol-Hee
Kim, and Young-Yun Kong " Mind Bomb-2
is an E3 Ligase for Notch Ligand". J
Biol Chem 2005, June 280:22335-342
- Kim HJ, Yoon MJ, Lee J, Penninger JM, Kong
YY " Osteoprotegerin ligand
induces beta-casein gene expression through
the transcription factor CCAAT/enhancer-binding
protein beta " J Biol Chem 2002
Feb 15;277(7) :5339-44.
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Division
of Molecular & Life Sciences| POSTECH |
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