Chin Ok Lee, Ph.D.

Professor
Department of Life Science
Division of Molecular and Life Sciences
Cellular Physiology

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Publications Abstract
E-mail colee@postech.ac.kr

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Profile |  Research Interests |  Selected Publications

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1972
1972-1976
1976-1992 
1991-1997
1993-Present
1998-Present  

: Ph. D. Indiana Univ. School of Medicine
: Postdoctoral Fellow, Univ. of Chicago
: Assistant, Associate, Full Professor
: Professor and Chairman, POSTECH
: Adjunct Prof. Cornell Univ. Med. Col.
: Visiting and Adjunct Prof. Rockefeller Univ.

 

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Cardiac Cellular Physiology
Dr. Lee's laboratory studies regulation of intracellular ions and their relations to changes of contractile force in cardiac muscle cells. Our research focuses on how signals through receptors modulate ionic channels and transporters, and cytosolic ion concentration. The emphasis of the present work is on regulation of intracellular Ca2+ and Na+ in single cells and multicellular preparations of cardiac muscles. We are also interested in molecular aspects of ion channels and transporters. Techniques used in Dr, Lee's laboratory include: isolation of cardiac myocytes and sinoatrial nodes; single cell voltage clamp; measurements of intracellular ions with fluorescent indicators and ion-selective microelectrodes.

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1. Su-Hyun Jo, Se-Young Choi, Kyong-Tai Kim, and Chin O. Lee, "Effects of polychlorinated Biphenyl 19 ( 2,2'6-Trichlorobiphenyl) on Contraction, Ca2+ Transient, and Ca2+ Current of Cardiac Myocytes", Journal of Cardiovascular Pharmacology, Vol.38(1), , pp.11-20 Lippincott Williams & Wilkins, Inc. (2001).

2. Jo, SH, CH. Cho, SW. Chae, CO. Lee, "Role of protein kinase C in α1-adrenergic regulation of aiNa in guinea pig ventricular myocytes", Am J Physiol, Vol.279:H1661-H1668American Physiological Society (2000).

3. Woo, S. H. and C. O. Lee., "Role of PKC in the effects of α1-adrenergic stimulation on Ca2+ transients, contraction and Ca2+ current in guinea-pig ventricular myocytes", Pflugers Archiv. (Eur. J. Physiol.), Vol.437, pp.335-344. (1999).

4. Choi, H.S., D. Y. Wang, D. Noble and C. O. Lee., "Effect of isoprenaline, carbachol and Cs+ on Na+ activity and pacemaker potential in rabbit SA node cells.", Am. J. Physiol. (Heart and Circulation), Vol.276(1 Pt 2), pp.H205-H214. (1999).

5. Woo, S. H. and C. O. Lee., "Effect of endothelin-1 on Ca2+ signals in guinea-pig ventricular myocytes: Role of protein kinase C", J. Mol. Cell. Cardiol, Vol.31, pp.631-643. (1999).

6. Injune Kim Gou Young Koh, and Chin O. Lee, "Identification of Alternatively Spliced Na+-Ca2+ Exchanger Isoforme Expressed in the Heart", Comp. Biochem. Physiol, Vol.119B: 157-161(1998)

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Division of Molecular & Life Sciences| POSTECH