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Byung-Ha Oh, Ph.D.
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Professor
Department of Life Science
Division
of Molecular and Life Sciences
Structural
Biology
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Publications
Abstract
E-mail bhoh@postech.ac.kr
Phone +82-54-279-2289(office)
+82-54-279-5994(lab.)
Laboratory Structural
Biology lab.
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Profile
| Research Interests
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Publications
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Profile
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1989
1989-1990
1991-1993
1993-1994
2000-present
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Ph.D.,
University of Wisconsin-Madison,
Post-Doc.,
University of Wisconsin-Madison
Post-Doc.,
University of California-Berkeley
Asso. Senior Investigator SmithKline
Beecham Pharmaceuticals, USA
Director,
National CRI Center for Biomolecular Interaction
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 TOP
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Research Interests
Structural Biology
Three-dimensional
structures of biomacromolecules have contributed
immensely to our current level of understanding
in biochemistry and molecular biology. Our
laboratory mainly studies structure-function relationship
of proteins. We have determined the three-dimensional
structures of a variety of proteins, including ketosteroid
isomerases from Psedomonas putida and Psedomonas
testosteroni. RNA helicase from hepatitis C
virus, maltogenic amylase from Thermus species,
novel phytase, human TRAIL/Apo-2L, TRAIL:DR5 complex,
and urease from Helicobacter pylori. Our
primary research tool is x-ray crystallographic
methods to solve and answer many biological problems
and questions, but we also use many other biochemical
and biophysical techniques such as nuclear magnetic
resonance spectroscopy, mass spectrometry, and calorimetry.
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Selected Publications
- Shin Cha, Min-Sung Kim, Yo Han Choi, Byung-Je Sung, Nam Kyu Shin, Hang-Cheol Shin, Young Chul Sung, Byung-Ha Oh, “2.8 Å Resolution Crystal Structure of Human TRAIL, a Cytokine With Selective Antitumor Activity”, Immunity 11, 253-261 (1999).
- Nam-Chul Ha, Byung-Chul Oh, Sejeong Shin, Hyun-Ju Kim, Tae-Kwang Oh, Young-Ok Kim, Kwan Yong Choi, Byung-Ha Oh, “Crystal Structures of a Novel, Thermostable Phytase in Partially and Fully Calcium-Loaded States”, Nat. Struct. Biol. 7, 147-153 (2000).
- Nam-Chul Ha, Sang-Taek Oh, Jae Young Sung, Kyeung Ah Cha, Mann Hyung Lee, Byung-Ha Oh, “Supramolecular Assembly and Acid-resistance of Helicobactoer pylori Urease”, Nat. Struct. Biol. 8, 505-509 (2001).
- Sejeong Shin, Tae-Hee Lee, Nam-Chul Ha, Hyun Min Koo, So-yeon Kim, Heung-Soo Lee, Yu Sam Kim, and Byung-Ha Oh, “A Novel Ser-cisSer-Lys catalytic Triad in a New Serine Hydrolase Fold Prevalent in Nature”, EMBO J. 21, 3139-3148 (2002).
- Min-Sung Kim, Minji Byun, Byung-Ha Oh, “Crystal structure of peptidoglycan recognition protein-LB from Drosophila melanogaster”, Nat. Immunol. 4, 787-793 (2003).
- Eui-Jeon Woo, Yeon-Gil Kim, Min-Sung Kim, Won-Deok Han, Sejeong Shin, Howard Robinson, Sam-Yong Park, Byung-Ha Oh, “Structural mechanism for inactivation and activation of CAD/DFF40 in the apoptotic pathway”, Mol. Cell 14, 531-539 (2004).
- Yeon-Gil Kim, Eun Ju Sohn, Jawon Seo, Kong-Joo Lee, Heung-Soo Lee, Inhwan Hwang, Malcolm Whiteway, Michael Sacher, Byung-Ha Oh, "Crystal structure of bet3 reveals a novel mechanism for Golgi localization of tethering factor TRAPP", Nat. Struct. Mol. Biol. 12, 38-45 (2005).
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Division
of Molecular & Life Sciences| POSTECH |
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