\

Roh, Tae-Young, Ph.D.

Assistant Professor
Division of Molecular and Life Sciences
System Genomics

Publications Abstract
E-mail tyroh@postech.ac.kr
Phone +82-54-279-2350(office)
          +82-54-279-8188(lab.)
Laboratory Lab. of System Genomics

Profile |  Research Interests  |  Selected Publications

Profile

Research Interests

In the post genome era, the importance of genomics, the study of an entire genome and epigenetics, heritable changes in gene expression patterns independent of DNA itself, has been raised. Our group is interested in the genome-wide analysis of epigenetic markers associated with cell growth, differentiation, senescence, and development of disease and systematic approach to the mechanism underlying epigenetic effects using one of next generation sequencing platforms (Illumina Genome Analyzer II).

1. Epigenetic modification
Comparative epigenetic information of normal/cancer cells or stem cells/differentiated cells could provide a valuable clue to identify targets for disease diagnosis and treatment.

2. Genome function
Transcriptional regulation occurs via interactions between proteins and functional elements on DNA. Novel functional elements could be found by intensive analysis of epigenome data.

3. Construction of database for epigenome and development of data analysis tool
Databases for high resolution and high throughput data generated from next generation sequencing will be constructed and applied to understand the molecular basis of individual gene transcription.

Selected Publications 

1. Epigenetic regulation in cell reprogramming revealed by genome-wide analysis. Epigenomics 3(1), 73-81 (2011)
2. Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation. Blood  116(3), 386-95 (2010)
3. Chromatin poises miRNA- and protein-coding genes for expression. Genome Res 19(10), 1742-51 (2009)
4. Chromatin signatures in multipotent human hematopoietic stem cells indicate the fate of bivalent genes during differentiation. Cell Stem Cell  4(1), 80-93 (2009)
5. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet  40(7), 897-903 (2008)
6. Dynamic regulation of nucleosome positioning in the human genome. Cell 132(5), 887-98 (2008)
7. High-resolution profiling of histone methylations in the human genome. Cell 129(4), 823-37 (2007)
8. Genome-wide prediction of conserved and nonconserved enhancers by histone acetylation patterns. Genome Res 17(1), 74-81 (2007)
9. The genomic landscape of histone modifications in human T cells. Proc Natl Acad Sci U S A 103(43), 15782-7 (2006)
10. Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes Dev 19(5), 542-52 (2005)
11. High-resolution genome-wide mapping of histone modifications. Nat Biotechnol  22(8), 1013-6 (2004)

Division of Molecular & Life Sciences| POSTECH