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Tae-Young Roh, Ph.D.
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Assistant Professor
Division
of Molecular and Life Sciences
Genomics, Biochemistry
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Publications
Abstract
E-mail tyroh@postech.ac.kr
Phone +82-54-279-2350(office)
+82-54-279-
(lab.)
Laboratory Lab. of System Genomics
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Profile
| Research Interests
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Publications
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Profile
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2002
2002-2007
2007-2008
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Ph.D. Seoul National University
Visiting Fellow, National Institutes of Health, Lab of Molecular Immunology
Research Fellow, National Institutes of Health, Lab of Molecular Immunology
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 TOP
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Research Interests
In the post genome era, the importance of genomics, the study of an entire genome and epigenetics, heritable changes in gene expression patterns independent of DNA itself, has been raised. Our group is interested in the genome-wide analysis of epigenetic markers associated with cell growth, differentiation, senescence, and development of disease and systematic approach to the mechanism underlying epigenetic effects using one of next generation sequencing platforms (Illumina Genome Analyzer II).
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1. Epigenetic modification
Comparative epigenetic information of normal/cancer cells or stem cells/differentiated cells could provide a valuable clue to identify targets for disease diagnosis and treatment.
2. Genome function
Transcriptional regulation occurs via interactions between proteins and functional elements on DNA. Novel functional elements could be found by intensive analysis of epigenome data.
3. Construction of database for epigenome and development of data analysis tool
Databases for high resolution and high throughput data generated from next generation sequencing will be constructed and applied to understand the molecular basis of individual gene transcription.
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Selected Publications
- Artem Barski*, Suresh Cuddapah*, Kairong Cui*, Tae-Young Roh*, Dustin E. Schones*, Zhibin Wang*, Gang Wei*, Iouri Chepelev and Keji Zhao (2007). High-Resolution Profiling of Histone Methylations in the Human Genome. Cell 129, 823-837 (* equal contribution)
- Tae-Young Roh, Gang Wei, Catherine M. Farrell and Keji Zhao (2007). Genome-wide prediction of conserved and non-conserved enhancers by histone acetylation patterns. Genome Research 17, 74-81
- Tae-Young Roh, Suresh Cuddapah, and Keji Zhao (2006). The Genomic Landscape of Histone Modifications in Human T cells. Proc. Natl. Acad. Sci. U.S.A. 103, 15782-15787
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- Tae-Young Roh, Suresh Cuddapah, and Keji Zhao (2005). Active chromatin domains are defined by acetylation islands revealed by genome-wide mapping. Genes & Dev. 19, 542-552
- Tae-Young Roh, Wing Chi Ngau, Kairong Cui, David Landsman & Keji Zhao (2004). High-resolution genome-wide mapping of histone modifications. Nature Biotechnology 22, 1013-1016
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Division
of Molecular & Life Sciences| POSTECH |
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