A research team of Department of Life Science’s Center for Biomolecular Recognition and Division of Molecular and Life Science, consisting of Professor Byung-Ha Oh, Doctor Jae-Sung Woo, and Doctor Jae-Hong Lim, has solved secrets of the ring-shaped molecular structure of the MukBEF condensin, the key mediator of chromosome condensation.In eukaryotic organisms, chromosomes are found in the nucleus of every cell. Before cell division, chromosomes are condensed, and the two replicated copies of the chromosomes are partitioned into the two daughter cells. In prokaryotic organisms, chromosome..
TGFβ ligands belonging to the Activin/Nodal family, induces mesoderm and endoderm, specifies the embryonic axes, promotes gastrulation movements, maintains pluripotency of embryonic stem cells, and determines left-right asymmetry in vertebrates. Activin/Nodal ligands signal through type I and type II transmembrane serine/threonine kinase receptors. Ligand binding induces the formation of heteromeric receptor complexes in which type II receptors phosphorylate and activate type I receptors. The activated type I receptors transduce the signal inside the cell through the phosphorylation of th..