Profile

Hyun-Suk Lim 사진
Profile.
Name Hyun-Suk Lim
Organization Div of Advanced Materials Science
Telephone 279-2131
E-mail hslim@postech.ac.kr
Homepage http://cbl.postech.ac.kr/

Education

  • 2000~2004 POSTECH (박사-화학)
  • 1991~1993 한양대학교 (석사-화학)
  • 1987~1991 한양대학교 (학사-화학)

Career

  • 2008~2012 : INDIANA UNIVERSITY
  • 2005~2008 : UT-SOUTHWESTERN MEDICAL CENTER
  • 1993~2005 : 중외제약 C&C연구소

Profession

Journal Papers

International

  • Intracellular and transdermal protein delivery mediated by non-covalent interactions with a synthetic guanidine-rich molecular carrier, International Journal of Pharmaceutics, , 528, 646-654 (2017)
  • Targeted Inhibition of the NCOA1/STAT6 Protein-Protein Interaction, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, , 139, 16056-16059 (2017)
  • Screening methods for identifying pharmacological chaperones, Molecular BioSystems, , 13, 638-647 (2017)
  • A chemical inhibitor of the Skp2/p300 interaction that promotes p53-mediated apoptosis, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, , 55, 602-606 (2016)
  • Converting One-Face α-Helix Mimetics into Amphiphilic α-Helix Mimetics as Potent Inhibitors of Protein-Protein Interactions, ACS Combinatorial Science, , 18, 36-42 (2016)
  • Oligomers of N-Substituted β(2)-Homoalanines: Peptoids with Backbone Chirality, Organic Letters, , 18, 3878-3681 (2016)
  • Skp2 Inhibitors: Novel Anticancer Strategies, Current Medicinal Chemistry, , 23, 2363-2379 (2016)
  • Synthesis and screening of small-molecule alpha-helix mimetic libraries targeting protein-protein interactions, CURRENT OPINION IN CHEMICAL BIOLOGY, , 24, 38-47 (2015)
  • Design, Solid-Phase Synthesis, and Evaluation of a Phenyl-Piperazine-Triazine Scaffold as alpha-Helix Mimetics, ACS COMBINATORIAL SCIENCE, , 16, 695-701 (2014)
  • Facile Method To Sequence Cyclic Peptides/Peptoids via One-Pot Ring-Opening/Cleavage Reaction, ORGANIC LETTERS, , 16, 5710-5713 (2014)
  • Potential pharmacological chaperones targeting cancer-associated MCL-1 and Parkinson disease-associated alpha-synuclein, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, , 111, 11007-11012 (2014)
  • Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines, ORGANIC & BIOMOLECULAR CHEMISTRY, , 10, 4229-4235 (2012)
  • Design and Facile Solid-Phase Synthesis of Conformationally Constrained Bicyclic Peptoids, ORGANIC LETTERS, , 13, 5012-5015 (2011)
  • Novel Pyrrolopyrimidine-Based alpha-Helix Mimetics: Cell-Permeable Inhibitors of Protein-Protein Interactions, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, , 133, 676-679 (2011)
  • A simple strategy for the construction of combinatorial cyclic peptoid libraries, CHEMICAL COMMUNICATIONS, , 46, 8615-8617 (2010)
  • Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates, NATURE CHEMICAL BIOLOGY, , 6, 258-260 (2010)
  • Non-proteolytic Regulation of p53-mediated Transcription through Destabilization of the Activator.Promoter Complex by the Proteasomal ATPases, JOURNAL OF BIOLOGICAL CHEMISTRY, , 284, 34522-34530 (2009)
  • Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle, CHEMICAL COMMUNICATIONS, , , 1064-1066 (2008)
  • Periodate-triggered cross-linking reveals Sug2/Rpt4 as the molecular target of a peptoid inhibitor of the 19S proteasome regulatory particle, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, , 129, 12936- (2007)
  • Identification of a peptoid inhibitor of the proteasome 19S regulatory particle, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, , 129, 7750- (2007)
  • Design and synthesis of a cell-permeable synthetic transcription factor mimic, JOURNAL OF COMBINATORIAL CHEMISTRY, , 9, 592-600 (2007)
  • A cell-permeable synthetic transcription factor mimic, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, , 46, 2865-2868 (2007)

Domestic Journal Papers

General Journal Papers

Conference Proceedings

Invited Talk or Presentations

  • A novel stabilization strategy of α-helix mimetic small molecules using hydrocarbon bridge, ., 0, 0, - (2015)
  • Cellular Uptake Evaluation of Triazine-Bridged Cyclic Peptoids, ., 0, 0, - (2015)
  • Design, Synthesis and Antimicrobial Activities of a Facile, Amphiphlic Peptidomimetics, ., 0, 0, - (2015)
  • Solid-Phase Synthesis and Sequence Analysis of Small Molecule alpha-Helix Mimetic Oligobenzamides, ., 0, 0, - (2015)
  • A One-Pot Ring-Opening and Cleavage Strategy for Constructing a Combinatorial Library of Bicyclic Peptoids, ., 0, 0, - (2015)
  • Oligomers of N-Substituted β2-Homoalanines: New Peptoid Foldamers, ., 0, 0, - (2015)
  • A One-Pot Ring-Opening/Cleavage Reaction for Constructing Combinatorial Cyclic Peptoid Libraries, ., 0, 0, - (2015)
  • On-Resin Protection for Efficient Sequence Determination of Cyclic Peptoids, ., 0, 0, - (2015)
  • A One-Pot Ring-Opening and Cleavage Strategy for a Combinatorial Library of Bicyclic Peptoids, ., 0, 0, - (2015)
  • Synthetic Antimicrobial Peptidomimetics Using Facile Amphiphilic Helical Scaffold, ., 0, 0, - (2015)
  • A Facile Method for Sequence Determination of Cyclic Peptides/Peptoids via CNBr-Mediated One-Pot Ring-Opening/Cleavage Reaction, ., 0, 0, - (2015)
  • Design, synthesis, and evaluation of phenyl-piperazine-triazine-based alhpa-helix mimetics as protein capture reagents, ., 0, 0, - (2015)
  • Targeting Protein-Protein Interactions Using alpha-Helix Mimetics with Easy Synthetic Manipulation, ., 0, 0, - (2015)
  • On-bead screening method for Rapid and Efficient Identification of α-Helix Mimetics Targeting Protein-Protein Interactions, ., 0, 0, - (2015)
  • A Simple Ring-Opening Strategy for Cyclic Peptide and Cyclic Peptoid Libraries, ., 0, 0, - (2015)
  • Structure-Activity Relationship Study of alpha-Helix Mimetics Targeting Protein-Protein Interactions, ., 0, 0, - (2015)
  • A Simple Strategy for Sequence Determination of Cyclic Peptides/Peptoids via CNBr-Mediated One-Pot Ring-Opening/Cleavage Reaction, ., 0, 0, - (2015)
  • A Combinatorial Library Approach for Rapid and Efficient Identification of α-Helix Mimetics Targeting Protein-Protein Interactions, ., 0, 0, - (2015)

Books

Research Activities

  • 새로운 개념의 항암제로서 SCFSKP2 UBIQUITIN LIGASE 저해제의 개발, 포항공과대학교 (2012-2013)
  • DEVELOPMENT OF CHEMICAL MODULATORS OF PROTEIN-PROTEIN INTERACTIONS, 포항공과대학교 (2012-2013)
  • 신규부임교수 기자재지원비, 포항공과대학교 (2012-2013)
  • DEVELOPMENT OF MCL-1 INHIBITORS USING Α-HELIX MIMETIC SMALL MOLECULES, 재단법인한국연구재단 (2012-2013)
  • DEVELOPMENT OF IMPROVED INHIBITORS OF MCL1/BH3 PROTEIN-PRO, 포항공대산학협력단 (2013-2013)
  • DEVELOPMENT OF CHEMICAL MODULATORS OF PROTEIN-PROTEIN INTERACTIONS, 포항공과대학교 (2013-2014)
  • (학생)인건비풀링과제, 포항공대산학협력단 (2013-2020)
  • DEVELOPMENT OF MCL-1 INHIBITORS USING Α-HELIX MIMETIC SMALL MOLECULES, 재단법인한국연구재단 (2013-2014)
  • 4.8324_1차년도 이월과제, 재단법인한국연구재단 (2013-2014)
  • 나노입자 기반 초거대 화합물 라이브러리를 통한 생분자의 기능 조절물질 개발, 포항공대산학협력단 (2014-2014)
  • 단백질 상호작용 제어를 위한 조절제 개발에 관한 연구(학과부담), 포항공과대학교 (2014-2015)
  • (임현석)BSRI_급성골수성백혈병 치료제로서 AML1-ETO저해제 개발, 포항공과대학교 (2014-2015)
  • (임현석)BSRI_다학제간 연구문화 조성을 위한 교수연구 모임, 포항공과대학교 (2014-2015)
  • DEVELOPMENT OF MCL-1 INHIBITORS USING Α-HELIX MIMETIC SMALL MOLECULES, 재단법인한국연구재단 (2014-2015)
  • 4.9628의 이월과제, 재단법인한국연구재단 (2014-2015)
  • TECHNOLOGY FOR FACILITATED DISCOVERY OF DRUG CANDIDATES BY AFFINITY-BASED HIGH THROUGHPUT SCREENING OF ULTRA LARGE COMBINATORIAL LIBRARIES, 대구경북첨단의료산업진흥재단 (2014-2015)
  • DEVELOPMENT OF “ANTIBODY SURROGATE MOLECULES” FOR TARGETING PROTEIN-PROTEIN INTERACTIONS, 재단법인 삼성미래기술육성재단 (2014-2019)
  • (BRSI-ISP)다학문적 연구문화 조성을 위한 교수연구미팅, 포항공과대학교 (2015-2016)
  • TECHNOLOGY FOR FACILITATED DISCOVERY OF DRUG CANDIDATES BY AFFINITY-BASED HIGH THROUGHPUT SCREENING OF ULTRA LARGE COMBINATORIAL LIBRARIES, 대구경북첨단의료산업진흥재단 (2015-2016)
  • [학부생연구프로그램]원형 N-치환기 Β2호모알라닌의 합성, 포항공과대학교 (2016-2016)
  • [BRSI-ISP]다학문적 연구문화 조성을 위한 교수연구미팅, 포항공과대학교 (2016-2017)
  • TECHNOLOGY FOR FACILITATED DISCOVERY OF DRUG CANDIDATES BY AFFINITY-BASED HIGH THROUGHPUT SCREENING OF ULTRA LARGE COMBINATORIAL LIBRARIES, 대구경북첨단의료산업진흥재단 (2016-2017)
  • PROTEOLYSIS TARGETING CHIMERA (PROTACS) 방법을 이용한 NCOA1 단백질의 분해, 포항공과대학교 (2017-2017)
  • 결합력 기반 스크리닝을 통한 신개념 화학유전학 연구, 재단법인한국연구재단 (2017-2018)
  • FAP(FIBROBLAST ACTIVATION PROTEIN) 저해제 개발, 보령제약(주)안산공장 (2017-2017)
  • DEVELOPMENT OF PEPTIDO-MIMETIC POTENTIATORS FOR REPOSITIONING DRUGS AGAINST DRUG-RESISTANT BACTERIA, 서울대학교 산학협력단 (2017-2018)
  • A NOVEL FORWARD CHEMICAL GENETIC APPROACH USING AFFINITY-BASED SCREENING, 재단법인한국연구재단 (2018-2019)
  • Development of peptido-mimetic potentiators for repositioning drugs against drug-resistant bacteria, 서울대학교 산학협력단 (2018-2019)
  • DEVELOPMENT OF PEPTIDO-MIMETIC POTENTIATORS FOR REPOSITIONING DRUGS AGAINST DRUG-RESISTANT BACTERIA, 서울대학교 산학협력단 (2018-2019)
  • 자체연구개발과제[2015년 신설], 포항공과대학교 (2018-2035)
  • 4.14678_이월과제, 재단법인한국연구재단 (2018-2019)

IP

  • 임현석,이영주, NCOA1/STAT6 단백질-단백질 상호작용을 저해하는 신규 스테이플 펩타이드 및 이의 용도, 한국, 10-2017-0139637 (2017)
  • 임현석,오미숙, 트리아진-피페라진 골격을 갖는 알파-헬릭스 유사체 및 이의 제조방법, 일본, 2017-502630 (2017)
  • 임현석,오미숙, 트리아진-피페라진 골격을 갖는 알파-헬릭스 유사체 및 이의 제조방법, USA, 15/326,422 (2017)
  • 임현석, 신규한 항암제로서 Skp2 저해제, 한국, 10-2015-0156519 (2015)
  • 임현석, 신규한 항암제로서 Skp2 저해제, 한국, 10-2015-0156519 (2015)
  • 임현석,오미숙, 트리아진-피페라진 골격을 갖는 알파-헬릭스 유사체 및 이의 제조방법, -, PCT/KR2014/0127 (2014)
  • 임현석,오미숙, 트리아진-피페라진 골격을 갖는 알파-헬릭스 유사체 및 이의 제조방법, 한국, 10-2014-0088669 (2012)