Research Area
Our research is directed to understand the structural and functional role of proteins involved in cell growth and proliferation as well as DNA repair. The proteins whose functional inactivation contributes to the formation of cancer are studied by x-ray crystallography as well as other biochemical techniques. The current projects include in human retinoblastoma viral oncogene complex, breast/ovary cancer susceptibility protein and proteins involved in the cell cycle regulation and DNA damage signaling pathway. The information obtained from these studies will help us (i) to understand how tumor inhibition and formation are regulated in the cell and (ii) to provide the framework to design the anti-cancer drug.
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Crystal structure of the eIF4A-PDCD4 complex J. H. Chang, Y. H. Cho, S. Y. Sohn, J. M. Choi, A. Kim, S. K. Jang and Y. Cho Proc Natl Acad Sci USA (2009) 106 : 3148-3153 |
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Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of the central zinc-binding domain of the human Mcm10 DNA-replication factor N. Y. Jung, W. J. Bae, J. H. Chang, Y. C. Kim and Y. Cho Acta Cryst. F Struct. Biol. Cryst. Commun. (2008) 64(Pt 6) : 495-7 |
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Crystal structure of the Mus81-Eme1 complex J. H. Chang, J. J. Kim, J. M. Choi, J. H. Lee and Y. Cho Genes & Dev. (2008) 22: 1093-1106 |
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Crystal structure of human DGCR8 core S. Y. Sohn, W. J. Bae, J. J. Kim, K. H. Yeom, V. N. Kim and Y. Cho Nat. Struct. Mol. Biol. (2007) 14(9):847-53 |
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Crystal structure of human GINS complex J. M. Choi, H. S. Lim, J. J. Kim, O. K. Song, and Y. Cho Genes & Dev. (2007) |
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Probing the roles of active site residues in the 3'-5' exonuclease of the Werner syndrome protein J. M. Choi, S. Y. Kang, W. J. Bae, K. S. Jin, M. Ree, Y. Cho J.Biol.Chem (2007) 282:9941-51 |
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Structure of a peptide:N-glycanase-Rad23 complex: Insight into
the deglycosylation for denatured glycoproteins
J. H. Lee, J. M. Choi , C. Lee , K. J. Yi , Y. Cho Proc Natl Acad Sci USA (2005) 102 : 9144-9149 |
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Structural basis for inhibition of the replication licensing factor Cdt1 by geminin C. Lee, B.S. Hong, J. M. Choi, Y. Kim,S. Watanabe, Y. Ishimi, T.Enomoto, S. Tada,Y.C. Kim and Y. Cho Nature (2004) 430: 913-7 |
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Probing the functional importance of the hexameric ring structure of RNase PH J. M. Choi, E. Y. Park, J. H. Kim, S. K. Chang and Y. Cho J. Biol. Chem. (2004) 279: 755-764 |
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Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet T. Kwon, J. H. Chang, E. Kwak, C. W. Lee, A. Joachimiak, Y. C. Kim, J. W. Lee and Y. Cho EMBO J. (2003) 22: 292-303 |
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C. Lee, J. H. Chang, H. S. Lee and Y. Cho Genes & Dev. (2002) 16: 3199-3212 |
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J. H. Chang, H. C. Kim, K. Y. Hwang, J. W. Lee, S. P. Jackson, S. D. Bell and Y. Cho J. Biol. Chem. (2002) 277: 34489-34498 |
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Interactions of SV40 large T antigen and other viral proteins with retinoblastoma tumour suppressor C. Lee and Y. Cho Rev Med Virol. (2002) 12(2):81-92. Review |
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H.Y. Kim, B.Y. Ahn and Y. Cho EMBO J. (2001) 20. 295-304 |
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K. Y. Hwang, J. H. Jung, S. -H. Kim, Y. S. Han and Y. Cho Nature Struc. Biol. (1999) 6. 691 - 696 |
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K. Y. Hwang, C. S. Cho, S. S. Kim, Y. G. Yu and Y. Cho Nature Struc. Biol. (1999) 6. 422 - 426 |
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S. Y. Kim, K. W. Hwang, S. H. Kim, Y. S. Han and Y. Cho J. Biol. Chem. (1999) 274. 11761 11767 |
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K. Y. Hwang, K. Baek, H. Y. Kim. and Y. Cho Nature Struc. Biol. (1998) 5, 707 - 713 |
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H. Y. Kim and Y. Cho Nature Struc. Biol. (1997) 4, 500-505 |