교원프로필

이승우 사진
교원에 대한 정보를 나타내는 표입니다.
성명 이승우
소속 생명과학과
전화번호 279-2355
E-mail monk@postech.ac.kr
Homepage http://www.postech.ac.kr/ibb/

학력

  • 1996.03 ~ 1999.02 포항공과대학교 (박사-생명과학)
  • 1994.03 ~ 1996.02 포항공과대학교 (석사-생명과학)
  • 1989.03 ~ 1994.02 포항공과대학교 (학사-생명과학)

주요경력

  • 2008.10 ~ 2012.01 : LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
  • 2003.06 ~ 2008.10 : LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY
  • 1998.03 ~ 2003.06 : POSTECH

전문분야

  • T 세포 면역학
  • 조혈모세포
  • 항암 면역학
  • 점막 면역학
  • 암 줄기세포

학술지

국제전문학술지

  • Airway G-CSF identifies neutrophilic inflammation and contributes to asthma progression, EUROPEAN RESPIRATORY JOURNAL, , 55, - (2020)
  • Tough and Immunosuppressive Titanium-Infiltrated Exoskeleton Matrices for Long-Term Endoskeleton Repair, ACS Applied Materials & Interfaces, , 11, 9786-9793 (2019)
  • Pathogenicity of the H1N1 influenza virus enhanced by functional synergy between the NPV100I and NAD248N pair, PLoS ONE, , 14, - (2019)
  • The Interferon-Inducible Proteoglycan Testican-2/SPOCK2 Functions as a Protective Barrier against Virus Infection of Lung Epithelial Cells, JOURNAL OF VIROLOGY, , 93, - (2019)
  • Bone marrow CX3CR1(+) mononuclear cells relay a systemic microbiota signal to control hematopoietic progenitors in mice, BLOOD, , 134, 1312-1322 (2019)
  • Eosinophil extracellular traps activate type 2 innate lymphoid cells through stimulating airway epithelium in severe asthma, ALLERGY, , , - (2019)
  • Cost-effective production of tag-less recombinant protein in Nicotiana benthamiana, PLANT BIOTECHNOLOGY JOURNAL, , 17, 1094-1105 (2019)
  • Evaluating Antitumor Activity of Kiatomab by Targeting Cancer Stem Cell Specific KIAA1114 Antigen in Mice, IMMUNE NETWORK, , 19, - (2019)
  • PD-1 deficiency protects experimental colitis via alteration of gut microbiota (vol 50, pg 578, 2017), BMB Reports, , 51, 314-314 (2018)
  • TRAF6 Distinctly Regulates Hematopoietic Stem and Progenitors at Different Periods of Development in Mice, MOLECULES AND CELLS, , 41, 753-761 (2018)
  • Bacterial outer membrane vesicles suppress tumor by interferon-gamma- mediated antitumor response, NATURE COMMUNICATIONS, , 8, - (2017)
  • PD-1 deficiency protects experimental colitis via alteration of gut microbiota, BMB REPORTS, , 50, 578-583 (2017)
  • Plasmacytoid dendritic cells contribute to the protective immunity induced by intranasal treatment with fc-fused interleukin-7 against lethal influenza virus infection, Immune Network, , 17, 343-351 (2017)
  • Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5, Nature Communications, , 8, 10637- (2017)
  • Erratum: Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection, Immune Network, , 17, 460-460 (2017)
  • In vivo longitudinal visualization of bone marrow engraftment process in mouse calvaria using two-photon microscopy, Scientific Reports, , 7, 440971- (2017)
  • Lineage re-commitment of CD4CD8αα intraepithelial lymphocytes in the gut, BMB Reoprts, , 49, 11-17 (2016)
  • Intranasal introduction of Fc-fused interleukin-7 provides long-lasting prophylaxis from lethal influenza infection., Journal of Virology, , 90, 2273-2284 (2016)
  • Noninvasive Transdermal Vaccination Using Hyaluronan Nanocarriers and Laser Adjuvant, Advanced Functional Materials, , 26, 2512-2522 (2016)
  • Intravaginal Administration of Fc-Fused IL7 Suppresses the Cervicovaginal Tumor by Recruiting HPV DNA Vaccine-Induced CD8 T Cells, Clinical Cancer Research, , 22, 5898-5908 (2016)
  • Protective effects of Fc-fused PD-L1 on two different animal models of colitis, GUT, , 64, 260-271 (2015)
  • Bacterial Protoplast-Derived Nanovesicles as Vaccine Delivery System against Bacterial Infection, NANO LETTERS, , 15, 266-274 (2015)
  • 4-1BB Ligand Signaling to T Cells Limits T Cell Activation, JOURNAL OF IMMUNOLOGY, , 194, 134-141 (2015)
  • Altered Gut Microbiota Composition in Rag1-deficient Mice Contributes to Modulating Homeostasis of Hematopoietic Stem and Progenitor Cells, Immune Network, , 15, 252-259 (2015)
  • Intravaginal Fc-fused IL-7 attract DNA vaccine-induced CD8 T cell in the genital tract, CYTOKINE, , 76, 80-80 (2015)
  • Galectin-9 controls the therapeutic activity of 4-1BB-targeting antibodies, JOURNAL OF EXPERIMENTAL MEDICINE, , , 1433-1448 (2014)
  • Crucial roles of Interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity, JOURNAL OF VIROLOGY, , , 8998-9009 (2014)
  • Protective effects of Fc-fused PD-L1 on two different animal models of colitis, GUT, , , - (2014)
  • KIAA1114, a full-length protein encoded by the trophinin gene, is a novel surface marker for isolating tumor-initiating cells of multiple hepatocellular carcinoma subtypes, ONCOTARGET, , 5, 1226-1240 (2014)
  • 4-1BB Cutting Edge: Controls Regulatory Activity in Dendritic Cells through Promoting Optimal Expression of Retinal Dehydrogenase., JOURNAL OF IMMUNOLOGY, , 189, 2687-2701 (2012)
  • Nitric Oxide Modulates TGF-beta-Directive Signals To Suppress Foxp3(+) Regulatory T Cell Differentiation and Potentiate Th1 Development, JOURNAL OF IMMUNOLOGY, , 186, 6972-6980 (2011)
  • Biphasic role of 4-1BB in the regulation of mouse cytomegalovirus-specific CD8 T cells, EUROPEAN JOURNAL OF IMMUNOLOGY, , 40, 2762-2768 (2010)

국내전문학술지

  • 소나 시스템 설계를 위한 FFR 트랜스듀서 어레이의 등가회로 모델링, 전기학회논문지, , 66, 629-635 (2017)

일반학술지

학술회의논문

  • Commensal-induced inflammatory cytokines control the steady state expansion of multipotent progenitors, 제40차 하계 세포생물학회, 0, 0, - (2015)
  • Gut microbiota controls the homeostasis of hematopoietic stem cells, 2014 KAIST-INSERM-IBS JOINT SYMPOSIUM ON CANCER, INFLAMMATION AND EPIGENETICS, 0, 0, - (2014)
  • Chronic lung inflammation programs the lineage-biased fate of hematopoietic stem and progenitor cells, THE 34TH SCIENTIFIC CONGRESS OF THE KOREAN MEDICAL ASSOCIATION, 0, 0, - (2014)
  • 4-1BB controls the regulatory activity of intestinal dendritic cells, ., 0, 0, - (2012)
  • 4-IBB controls the regulatory activity of intestinal dendritic cells, ., 0, 0, - (2012)

학회발표

  • Lactic Acid Bacteria-Derived Protein, P14, has Immunomodulatory Properties and Regulates Intestinal Inflammation with Probiotic-mediated Drug Delivery System, KAI International Meeting 2019, 0, 0, - (2019)
  • Enhancement of Influenza viral pathogenicity by co-varying viral protein pair, KSBMB International Conference 2019, 0, 0, - (2019)
  • Protective role of a novel interferon-inducible proteoglycan, SPOCK2, against influenza virus infection, KSBMB International Conference 2019, 0, 0, - (2019)
  • Hyleukin-7, the Fc-fused interleukin-7, generates anti-tumor activity by modulating both adaptive and innate immune cells in the tumor microenvironment, AACR Annual Meeting 2019 Proceedings, 0, 0, - (2019)
  • Kiatomab is a Novel Antitumor Monoclonal Antibody Targeting Cancer Stem Cells, FIMSA 2018, 0, 0, - (2018)
  • Preclinical evaluation of the anti-tumor activity of Fc-fused interleukin-7 in both monotherapy and combination therapy, KAI International Meeting 2018, 0, 0, - (2018)
  • Programming of epithelial resident memory T cells by mucosal dendritic cells and the gut microenvironment, MICS 2018, 0, 0, - (2018)
  • Preclinical evaluation of the anti-tumor activity of Fc-fused interleukin-7 in both monotherapy and combination therapy, AACR Annual Meeting 2018, 0, 0, - (2018)
  • Alveolar type II cell derived G-CSF contributes to neutrophilic sthma by modulating hematopoiesis in the bone marrow, Keystone Symposia Conference, 0, 0, - (2018)
  • Microbiota-induced inflammatory cytokines by dendritic cells control hematopoietic progenitors, Microbiota-induced inflammatory cytokines by dendritic cells control hematopoietic progenitors, 0, 0, - (2017)
  • Kiatomab is a Novel Antitumor Monoclonal Antibody Targeting Cancer Stem Cell, Kiatomab is a Novel Antitumor Monoclonal Antibody Targeting Cancer Stem Cell, 0, 0, - (2017)
  • PD-1 Deficiency Protects Experimental Colitis via Alteration of Gut Microbiota, PD-1 Deficiency Protects Experimental Colitis via Alteration of Gut Microbiota, 0, 0, - (2017)
  • Identification of Lactobacillus strains for development of vegan probiotic products with anti-obesity and well-aging effects, Identification of Lactobacillus strains for development of vegan probiotic products with anti-obesity and well-aging effects, 0, 0, - (2017)
  • C14ORF1 as a novel diagnostic and therapeutic mAbtargeting Pancreatic Cancer Stem cells, C14ORF1 as a novel diagnostic and therapeutic mAbtargeting Pancreatic Cancer Stem cells, 0, 0, - (2017)
  • PD-1 Deficiency Protects Experimental Colitis via Alteration of Gut Microbiota, PD-1 Deficiency Protects Experimental Colitis via Alteration of Gut Microbiota, 0, 0, - (2017)
  • Identification of Lactobacillus strains for development of vegan probiotic products with anti-obesity and well-aging effects , 2017 INTERNATIONAL SCIENTIFIC CONFERENCE PROBIOTICS AND PREBIOTICS, 0, 0, - (2017)
  • Microbiota-induced inflammatory cytokines by dendritic cells control hematopoietic progenitors, Microbiota-induced inflammatory cytokines by dendritic cells control hematopoietic progenitors, 0, 0, - (2017)
  • Commensal-induced inflammatory cytokines control the steady state expansion of hematopoietic multipotent progenitors, ., 0, 0, - (2015)
  • Commensal-induced inflammatory cytokines control the steady state expansion of multipotent progenitors, ., 0, 0, - (2015)
  • Gut microbiota controls the homeostasis of hematopoietic stem cells, ., 0, 0, - (2014)
  • Chronic lung inflammation programs the lineage-biased fate of hematopoietic stem and progenitor cells, ., 0, 0, - (2014)
  • 4-1BB controls the regulatory activity of intestinal dendritic cells, ., 0, 0, - (2012)
  • 4-IBB controls the regulatory activity of intestinal dendritic cells, ., 0, 0, - (2012)

단행본

연구실적

  • 장내세균에 의한 조혈모세포 항상성 조절에 관한 연구, 포항공과대학교 (2012-2013)
  • 신규부임교수 기자재지원비, 포항공과대학교 (2012-2013)
  • 장내세균에 의한 조혈모세포의 항상성 조절, 재단법인한국연구재단 (2012-2013)
  • 장내세균에 의한 조혈모세포 항상성 조절에 관한 연구, 포항공과대학교 (2013-2014)
  • 신규부임교수 기자재지원비, 포항공과대학교 (2013-2014)
  • 다학제간 면역학 공동연구를 위한 포스텍 포럼, 포항공과대학교 (2013-2014)
  • 장내세균의 의한 조혈모세포의 항상성 조절, 재단법인한국연구재단 (2013-2014)
  • 신규부임교수 기자재지원비(대학부담), 포항공대산학협력단 (2014-2015)
  • (이승우)BSRI_장 오가노이드 배양을 이용한 장 상피조직 림프구 분화과정, 포항공과대학교 (2014-2015)
  • 학생인건비통합관리과제, 포항공대산학협력단 (2014-2020)
  • 장내세균에 의한 조혈모세포의 항상성 조절, 재단법인한국연구재단 (2014-2015)
  • 신규 항암 면역치료 약물의 비임상 활성, 효능 평가 및 바이오마커 연구, (주)유한양행 (2014-2015)
  • 생물공학연구소 부서연구관리비, 포항공대산학협력단 (2015-2020)
  • [학생연구프로그램_이은정]장 점막 특이 세포 독성 CD4+T 세포의 기능 분화에 관한 연구, 포항공과대학교 (2015-2015)
  • [학생연구프로그램_김소라]IL-7이 조혈모세로의 항상성 조절에 미치는 역할에 대한 연구, 포항공과대학교 (2015-2015)
  • 시험물질에 대한 대장암 종양 모델에서의 면역 세포 분석 연구, (주)유한양행 (2016-2019)
  • 고발현 단백질 생체효능검증기술 개발, 명지대학교산학협력단 (2016-2016)
  • IL-7-HYFC의 항암면역 효능 검증, NEOIMMUNETECH INC (2016-2018)
  • 암 면역 연구회(포-가 기획프로젝트팀), 포항공과대학교 (2016-2017)
  • 유산균 이용 난치성 장질환 치료 효능 및 기전 연구, (주)쎌바이오텍 (2016-2016)
  • 유용 유산균 생리활성 분석, (주)쎌바이오텍 (2016-2018)
  • 비건 제품에 대한 항비만 기전 및 장내균총 변화, 바이오코젠 주식회사 (2016-2016)
  • 항암면역항체를 이용한 면역 활성화 분석, 에이비엘바이오 주식회사 (2017-2018)
  • 림프구 감소증 모델에서 IL-7 HYFC의 효능 검증, NEOIMMUNETECH INC (2017-2017)
  • 정제 다당체의 활성 평가, 아이진(주) (2017-2017)
  • 비건 제품에 대한 항비만 기전 및 장내균총 변화, 바이오코젠 주식회사 (2017-2017)
  • 고발현 단백질 생체효능검증기술 개발, 명지대학교산학협력단 (2017-2017)
  • IL-7-HYFC가 폐로 전이되는 암에 끼치는 역할에 관한 연구, 포항공과대학교 (2017-2017)
  • 유산균 이용 난치성 장질환 치료 효능 및 기전 연구, (주)쎌바이오텍 (2017-2017)
  • 골수 내 수지상세포의 조혈모세포 조절, 재단법인한국연구재단 (2017-2018)
  • 인공지능 및 수학적 모델링의 생물학 연구 적용, 포항공과대학교 (2017-2018)
  • 항암면역치료를 위한 BISPECIFIC HYFC 융합단백질 개발, 재단법인한국연구재단 (2017-2017)
  • 4.13679 이월과제, (주)쎌바이오텍 (2017-2017)
  • GX-17에 의한 조혈모세포의 말초혈액으로 이동에 대한 연구, ㈜제넥신 (2017-2017)
  • 연구개발과제[2015년 신설], 포항공과대학교 (2017-2030)
  • 항암면역치료를 위한 BISPECIFIC HYFC 융합단백질 개발, 재단법인한국연구재단 (2018-2018)
  • 골수 내 수지상세포의 조혈모세포 조절, 재단법인한국연구재단 (2018-2019)
  • 림프구 감소증 모델에서 IL-7 HYFC의 효능 검증, NEOIMMUNETECH INC (2018-2019)
  • 유산균 이용 난치성 장질환 치료 효능 및 기전 연구, (주)쎌바이오텍 (2018-2018)
  • 4.14877 이월과제, 재단법인한국연구재단 (2018-2018)
  • 4.14893_이월 과제, (주)쎌바이오텍 (2018-2018)
  • 4.14781_이월과제, 재단법인한국연구재단 (2018-2019)
  • 항암면역항체를 이용한 면역 활성화 분석, 에이비엘바이오 주식회사 (2019-2020)
  • 항암면역치료를 위한 BISPECIFIC HYFC 융합단백질 개발, 재단법인한국연구재단 (2019-2019)
  • IL-7-HYFC의 항암면역 효능 검증, NEOIMMUNETECH INC (2019-2020)
  • 림프구 감소증 모델에서 IL-7 HYFC의 효능 검증, NEOIMMUNETECH INC (2019-2019)
  • IL-7의 항암면역반응 최적화 연구, NEOIMMUNETECH INC (2019-2020)
  • 유산균 이용 난치성 장질환 치료 효능 및 기전 연구, (주)쎌바이오텍 (2019-2019)
  • 4.14768_이월과제, (주)쎌바이오텍 (2019-2019)
  • NS101 + NT-I7 항암효능실험, 네오이뮨텍 유한회사 (2019-2019)
  • 항암면역치료를 위한 BISPECIFIC HYFC 융합단백질 개발, 과학기술정보통신부 (2020-2020)
  • IL-7-HYFC의 항암면역 효능 검증, NEOIMMUNETECH INC (2020-2021)
  • 림프구 감소증 모델에서 IL-7 HYFC의 효능 검증 (2차년), NEOIMMUNETECH INC (2020-2021)

IP

  • 이승우,김영민,김소라,박춘식, G-CSF 및 IL-1β를 이용한 호중구성 폐 염증질환의 진단, 예방 또는 치료용 조성물, -, PCT/KR2020/0064 (2020)
  • 이승우,김지혜,박수정,최동훈,양세환,이병하, METHOD OF TREATING A TUMOR WITH A COMBINATION OF IL-7 PROTEIN AND A BISPECIFIC ANTIBODY, -, 62/960,593 (2020)
  • 이승우,김지혜,박한욱,박수정,성영철, 변형된 인터루킨-7 및 TGF 베타 수용체 II를 포함하는 융합단백질 및 이의 용도, 한국, 10-2019-0146805 (2019)
  • 이승우,김영민,김소라,박춘식, G-CSF 및 IL-1β를 이용한 호중구성 폐 염증질환의 진단, 예방 또는 치료용 조성물, 한국, 10-2019-0057637 (2018)
  • 이승우,김영민,이승원, 인터류킨-17 억제제 및 종양괴사인자-알파 억제제를 유효성분으로 포함하는 호중구성 폐 염증질환의 예방 또는 치료용 약학적 조성물, -, PCT/KR2018/0088 (2018)
  • 이승우,김영민,이승원, 인터류킨-17 억제제 및 종양괴사인자-알파 억제제를 유효성분으로 포함하는 호중구성 폐 염증질환의 예방 또는 치료용 약학적 조성물, 한국, 10-2017-0175167 (2017)