Research

International

• Hashing the message with cells, Nature Chemical Biology, , 21, 166-167 (2025 )
• Vacciniarelated kinase 2 variants differentially affect breast cancer growth by regulating kinase activity, Oncology Research, , 32, 421-432 (2024 )
• RNABased Sensor Systems for Affordable Diagnostics in the Age of Pandemics, ACS Synthetic Biology, , 13, 1026-1037 (2024 )
• Logical regulation of endogenous gene expression using programmable multiinput processing CRISPR guide RNAs, Nucleic Acids Research, , 52, 8595-8608 (2024 )
• START A Versatile Platform for Bacterial Ligand Sensing with Programmable Performances, Advanced Science, , 11, - (2024 )
• Construction of multilayered gene circuits using denovodesigned synthetic transcriptional regulators in cellfree systems, Journal of Biological Engineering, , 18, - (2024 )
• Synthetic translational coupling element for multiplexed signal processing and cellular control, Nucleic Acids Research, , , - (2024 )
• A Theoretical Framework for Implementable Nucleic Acids Feedback Systems, Bioengineering Basel, , 10, - (2023 )
• Synthetic logic circuits using RNA aptamer against T7 RNA polymerase, Biotechnology journal, , 17, - (2022 )
• Cellular Computational Logic Using Toehold Switches, International Journal of Molecular Sciences, , 23, - (2022 )
• DNA Input Classification by a RiboregulatorBased CellFree Perceptron, ACS Synthetic Biology, , 11, 1510-1520 (2022 )
• ModelBased Investigation of the Relationship between Regulation Level and Pulse Property of I1FFL Gene Circuits, ACS Synthetic Biology, , 11, 2417-2428 (2022 )
• scaling up genelet circuits, Nature Chemistry, , 14, 1210-1211 (2022 )
• Signal amplification and optimization of riboswitchbased hybrid inputs by modular and titratable toehold switches, Journal of Biological Engineering, , 15, - (2021 )
• Multilevel Gene Regulation Using Switchable Transcription Terminator and Toehold Switch in Escherichia coli, APPLIED SCIENCESBASEL, , 11, - (2021 )
• CellFree Characterization of Coherent FeedForward LoopBased Synthetic Genetic Circuits, ACS Synthetic Biology, , 10, 1406-1416 (2021 )
• Design and evaluation of synthetic RNAbased incoherent feedforward loop circuits, Biomolecules, , 11, - (2021 )
• Datadriven network models for genetic circuits from timeseries data with incomplete measurements, JOURNAL OF THE ROYAL SOCIETY INTERFACE, , 18, 20210413- (2021 )
• Detection of pks Island mRNAs Using Toehold Sensors in Escherichia coli, Life, , 11, - (2021 )
• RNA nanotechnology in synthetic biology, CURRENT OPINION IN BIOTECHNOLOGY, , 63, 135-141 (2020 )
• On the stability of nucleic acid feedback control systems, AUTOMATICA, , 119, - (2020 )
• Autonomous dynamic control of DNA nanostructure selfassembly, NATURE CHEMISTRY, , 11, 510-520 (2019 )
• Robustness analysis of a nucleic acid controller for a dynamic biomolecular process using the structured singular value, JOURNAL OF PROCESS CONTROL, , 78, 34-44 (2019 )
• CellFree Synthetic Biology Platform for Engineering Synthetic Biological Circuits and Systems, Methods and Protocols, , 2, 39- (2019 )
• PID and State Feedback Controllers Using DNA Strand Displacement Reactions, IEEE Control Systems Letters, , 3, 805-810 (2019 )
• Programmable CRISPRCas Repression Activation and Computation with SequenceIndependent Targets and Triggers, ACS SYNTHETIC BIOLOGY, , 8, 1583-1589 (2019 )
• De novodesigned translationrepressing riboregulators for multiinput cellular logic, NATURE CHEMICAL BIOLOGY, , 15, 1173-+ (2019 )
• Ribocomputing Cellular Logic Computation Using RNA Devices, BIOCHEMISTRY, , 57, 883-885 (2018 )
• A coarsegrained model captures the temporal evolution of DNA nanotube length distributions, Natural Computing, , 17, 183-199 (2018 )
• Complex cellular logic computation using ribocomputing devices, NATURE, , 548, 117-121 (2017 )
• Proportional–Integral Degradation Control Allows Accurate Tracking of Biomolecular Concentrations With Fewer Chemical Reactions, IEEE Life Sciences Letters, , 2, 55-58 (2016 )
• Molecular Titration Promotes Oscillations and Bistability in Minimal Network Models with Monomeric Regulators, ACS Synthetic Biology, , 5, 321-333 (2016 )
• Rapidly characterizing the fast dynamics of RNA genetic circuitry with cellfree transcription–translation TXTL systems, ACS Synthetic Biology, , 4, 503-515 (2015 )
• Computational design of nucleic acid feedback control circuits, ACS Synthetic Biology, , 3, 600-616 (2014 )
• Load Capacity Improvements in Nucleic Acid Based Systems Using Partially Open Feedback Control, ACS Synthetic Biology, , 3, 617-626 (2014 )
• Synthetic circuit for exact adaptation and foldchange detection, NUCLEIC ACIDS RESEARCH, , 42, 6078-6089 (2014 )
• Gene circuit performance characterization and resource usage in a cellfree “breadboard”, ACS Synthetic Biology, , 3, 416-425 (2014 )
• Diversity in the dynamical behaviour of a compartmentalized programmable biochemical oscillator, Nature Chemistry, , 6, 295-302 (2014 )
• Ensemble Bayesian Analysis of Bistability in a Synthetic Transcriptional Switch, ACS Synthetic Biology, , 1, 299-316 (2012 )
• The expression of phosphoAKT1 and phosphoMTOR is associated with a favorable prognosis independent of PTEN expression in intrahepatic cholangiocarcinomas, MODERN PATHOLOGY, , 25, 131-139 (2012 )
• Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma, ANNALS OF SURGICAL ONCOLOGY, , 19, 404-411 (2012 )
• Overexpression of renal tumor antigen is associated with tumor invasion and poor prognosis of hepatocellular carcinoma, Annals of Surgical Oncology, , 19, 404-411 (2012 )
• Timing molecular motion and production with a synthetic transcriptional clock, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAPHYSICAL SCIENCES, , 108, E784-E793 (2011 )
• Synthetic in vitro transcriptional oscillators, Molecular Systems Biology, , 7, 465- (2011 )
• Overexpression of HighMobility Group Box 2 Is Associated with Tumor Aggressiveness and Prognosis of Hepatocellular Carcinoma, CLINICAL CANCER RESEARCH, , 16, 5511-5521 (2010 )
• Epithelialmesenchymal transition gene signature to predict clinical outcome of hepatocellular carcinoma, CANCER SCIENCE, , 101, 1521-1528 (2010 )
• Realtime reverse transcription PCR analysis for validation of transketolase gene in hepatocellular carcinoma tissues, BioChip Journal, , 3, 130-138 (2009 )
• Expression of cystathionine βsynthase is downregulated in hepatocellular carcinoma and associated with poor prognosis, ONCOLOGY REPORTS, , 21, 1449-1454 (2009 )
• Increased Expression of Autophagy Protein Beclin1 and LC3 in Highgrade Hepatocellular Carcinoma and Metastatic Carcinoma, BioChip Journal, , 3, 316-325 (2009 )
• Proteomic Profiling of Human Hepatocellular Carcinoma Tissues by TwoDimensional Electrophoresis and Mass Spectrometry, BIOCHIP JOURNAL, , 3, 237-248 (2009 )
• Expression of nicotinamide Nmethyltransferase in hepatocellular carcinoma is associated with poor prognosis, journal of experimental and clinical cancer research, , 28, 20- (2009 )
• Construction of an in vitro bistable circuit from synthetic transcriptional switches, Molecular Systems Biology, , 2, 68- (2006 )

Invited Talk or Presentations

• Development of a Signal Amplifier Utilizing Toehold Switch Modulation for a Riboswitchbased Vitamin B12 Sensor, , 0, 0, - (2024)
• Development and optimization of signal amplifier for riboswitchbased coenzyme B12 sensor using toehold switches modulator, , 0, 0, - (2023)
• Fluorescent Aptamer Based Gene detection, , 0, 0, - (2023)
• Detection of pks Island mRNAs Using Toehold Sensors in Escherichia coli, , 0, 0, - (2023)
• Logical Regulation of Endogenous Gene Expression with a Conditional Guide RNA Mediated CRISPR System, , 0, 0, - (2023)
• Design and Evaluation of Synthetic RNABased Incoherent FeedForward Loop Circuits, , 0, 0, - (2023)
• 토홀드 스위치 기반 유전자 조절자 접근법을 사용한 리보스위치 기반 센서 성능 최적화, , 0, 0, - (2023)
• Riboswitchbased Coenzyme B12 Sensor Signal Amplifier Development Using Toehold Switches Modulator, , 0, 0, - (2023)
• Modular and Titratable Toehold Switches for Amplifying and Optimizing RiboswitchBased Hybrid Inputs, , 0, 0, - (2023)
• Optimizing RiboswitchBased Hybrid Inputs for Coenzyme B12 Detection using Modular and Titratable Toehold Switches for Signal Amplification, , 0, 0, - (2023)
• Logical Regulation of Endogenous Gene Expression with a Conditional Guide RNA Mediated CRISPR System, , 0, 0, - (2022)
• Regulation of Endogenous Genes of Energy Metabolism Using Programmable MultiInput Processing CRISPR Guide RNAs, , 0, 0, - (2022)
• Repurposing translational coupling to improve the functionality of denovodesigned riboregulator, , 0, 0, - (2022)
• Regulation of Endogenous Gene Expression with a Computing CRIPSRCas System, , 0, 0, - (2022)
• Tuning of Coenzyme B12 RiboswitchBased Sensor for Signal Amplification with Toehold Switch Modulator, , 0, 0, - (2022)
• Tuning of Coenzyme B12 Riboswitch sensor for signal amplification with toehold switch, , 0, 0, - (2022)
• Development of signal amplified riboswitchbased coenzyme B12 sensor by toehold switches modulator , , 0, 0, - (2022)
• Multiinput cellular logic computation using computable guide RNAs, , 0, 0, - (2022)
• Cellular computational logic using toehold switches, , 0, 0, - (2022)
• Construction of Synthetic RNABased Incoherent FeedForward Loop Circuits in Escherichia coli, , 0, 0, - (2022)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2021)
• Signal Amplification of Riboswitchbased Hybrid Inputs by Modular and Titratable Toehold Switches, , 0, 0, - (2021)
• Design and Evaluation of Synthetic RNABased Incoherent Feedforward Loop Circuits, , 0, 0, - (2021)
• Cellular Arithmetic Logic Unit Using Toehold Switches , , 0, 0, - (2021)
• Detection of pks island mRNAs Using Toehold Sensors in Escherichia Coli , , 0, 0, - (2021)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2021)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2020)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2020)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2019)
• Ribocomputing Cellular Logic Computation using RNA Devices, , 0, 0, - (2019)
• Ribocomputing Leveraging RNA for computation in the cell, , 0, 0, - (2019)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2018)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2018)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2018)
• Ribocomputing Leveraging RNA for Computation in the Cell, , 0, 0, - (2018)