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POSTECH

Education

  • 2011.10 ~ 2015.09 UNIV. OF OXFORD (박사-Chemical Biology)
  • 2006.03 ~ 2008.02 한국과학기술원 (석사-화학)
  • 2000.03 ~ 2006.02 연세대학교 (학사-화학)

Career

  • 2019.11 ~ 2021.01 NORTHWESTERN UNIVERSITY
  • 2015.10 ~ 2016.09 UNIVERSITY OF OXFORD DEPT. OF CHEMISTRY

Journal Papers

International
  • Expanding the Scope of RibosomeMediated Biosynthesis iin vitroi using tRNAAminoacylating Ribozyme, Israel Journal of Chemistry, , 64, - (2024 )
  • CellFree Systems Ideal Platforms for Accelerating the Discovery and Production of PeptideBased Antibiotics, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, , 25, - (2024 )
  • Cellfree Biosynthesis of Peptidomimetics, Biotechnology and Bioprocess Engineering, , , - (2023 )
  • Ribosomemediated biosynthesis of pyridazinone oligomers in vitro, Nature Communications, , 13, - (2022 )
  • Threedimensional structureguided evolution of a ribosome with tethered subunits, Nature Chemical Biology, , 18, 990-998 (2022 )
  • Programmable Synthesis of Biobased Materials Using CellFree Systems, Advanced Materials, , , - (2022 )
  • Ribosomemediated incorporation of fluorescent amino acids into peptides in vitro, Chemical Communications, , 57, 2661-2664 (2021 )
  • Engineering molecular translation systems, Cell Systems, , 12, 593-607 (2021 )
  • A human protein hydroxylase that accepts Dresidues, Communications Chemistry, , 3, - (2020 )
  • Ribosomemediated polymerization of long chain carbon and cyclic amino acids into peptides in vitro, Nature Communications, , 11, - (2020 )
  • Ribosomal incorporation of cyclic betaamino acids into peptides using in vitro translation, Chemical Communications, , 56, 5597-5600 (2020 )
  • Expanding the limits of the second genetic code with ribozymes, Nature Communications, , 10, - (2019 )
  • Semisynthetic Nanoreactor for Reversible SingleMolecule Covalent Chemistry, ACS Nano, , 10, 8843-8850 (2016 )
  • De novo assembly and nextgeneration sequencing to analyse fulllength gene variants from codonbarcoded libraries, NATURE COMMUNICATIONS, , 6, - (2015 )
  • Semisynthetic protein nanoreactor for singlemolecule chemistry, Proceedings of the National Academy of Sciences of the United States of America, , 112, 13768-13773 (2015 )
  • Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolylhydroxylation, Proceedings of the National Academy of Sciences of the United States of America, , 111, 13331-13336 (2014 )
  • ‘Shotgun DNA synthesis’ for the highthroughput construction of large DNA molecules, Nucleic Acids Research, , 40, - (2012 )
  • Use of model peptides reaction for the characterization of a kineticallycontrolled ligation, Bioconjugate Chemistry, , 22, 1645-1649 (2011 )
  • NiSiO2yolkshell nanoreactor catalysts High temperature stability and recyclability, Journal of Materials Chemistry, , 20, 1239-1246 (2009 )
  • A nanoreactor framework of AuSiO2 yolkshell structure for catalytic reduction of pnitrophenol, Advanced Materials, , 20, - (2008 )
  • Precise tuning of porosity and surface functionality in AuSiO2 nanoreactors for high catalytic efficiency, Chemistry of Materials, , 20, 5839-5844 (2008 )
General Journal Journal
  • 비천연 아미노산 도입을 위한 리보솜 및 단백질번역체 엔지니어링 연구 동향, News Information for Chemical Engineers NICE, , 42, 520-529 (2024 )
  • 무세포cellfree 시스템을 이용한 펩타이드모방분자 peptidomimetics 합성 동향, 한국 생물공학회 소식지, , , - (2022 )

IP

  • 이준구,이강훈, 아실화된 tRNA, 리보솜 촉매를 이용한 약리 활성 모티프가 도입된 펩타이드 및 그의 제조방법, USA, 18/796,506 (P202)
  • 이준구,이강훈, 아실화된 tRNA, 리보솜 촉매를 이용한 약리 활성 모티프가 도입된 펩타이드 및 그의 제조방법, 한국, 10-2024-0095918 (P202)
  • 이준구,조남진,방서연,김도현, 맞춤형 단백질 합성을 위한 유전체 가공 균주 제작 및 세포파쇄액 제작 방법, 한국, 10-2024-0048919 (IP24)
  • 이준구,이강훈, 아실화된 tRNA, 리보솜 촉매를 이용한 약리 활성 모티프가 도입된 펩타이드 및 그의 제조방 법, 한국, 10-2023-0114636 (2023)
  • 이준구,이강훈, 아실화된 tRNA, 리보솜 촉매를 이용한 약리 활성 모티프가 도입된 펩타이드 및 그의 제조방법, 한국, 10-2023-0114636 (2023)

Book

  • Engineering ribosomes for natural product biosynthesis Comprehensive Natural Products III Chemistry and Biology, 4238, Lee, JG (2020 )

Invited Talk or Presentations

  • Enabling new chemistry by cellfree systems, , 0, 0, - (2024)
  • Ribosomemediated biosynthesis of pharmacophores, , 0, 0, - (2023)
  • Ribosomemediated biosynthesis of pharmacophore, , 0, 0, - (2023)
  • Engineering Molecular Translation Systems for Biosynthesis of HighValue Materials in vitro, , 0, 0, - (2023)
  • Ribosomemediated biosynthesis of pharmacophores, , 0, 0, - (2023)
  • Ribosomemediated biosynthesis of pharmacophores, , 0, 0, - (2023)
  • Ribosomemediated biosynthesis in vitro, , 0, 0, - (2022)
  • Ribosomemediated biosynthesis in vitro, , 0, 0, - (2022)
  • Ribosomemediated polymerization with novel chemistries, , 0, 0, - (2022)
  • Engineering Molecular Translation Systems, , 0, 0, - (2022)
  • Engineering Molecular Translation Systems, , 0, 0, - (2022)
  • Engineering Molecular Translation Systems, , 0, 0, - (2022)
  • Engineering Molecular Translation Systems, , 0, 0, - (2022)
  • Engineering Molecular Translation Systems, , 0, 0, - (2022)
  • Engineering Molecular Translation Systems, , 0, 0, - (2021)
  • "Engineering Molecular Translation Systems ", , 0, 0, - (2021)
  • Expanding the limits of the second genetic code with ribozymes, , 0, 0, - (2021)
  • 스무색 만으로 완성하지 못하는 단백질 디자인, , 0, 0, - (2021)

Research Activities

  • , 포항공과대학교 (2021-2022)
  • REPURPOSING THE TRANSLATIONAL MACHINERY FOR THE SYNTHESIS OF SEQUENCE-DEFINED POLYMER, 재단법인한국연구재단 (2021-2022)
  • , 재단법인한국연구재단 (2022-2023)
  • , 포항공과대학교 (2022-2023)
  • , 포항공과대학교 (2022-2023)
  • , 한국산업기술기획평가원 (2022-2022)
  • , 재단법인한국연구재단 (2022-2023)
  • , 삼성전자(주) (2022-2022)
  • , 삼성전자(주) (2022-2025)
  • , 포스코홀딩스(주) (2022-2023)
  • , 포항공대산학협력단 (2022-2023)
  • REPURPOSING THE TRANSLATIONAL MACHINERY FOR THE SYNTHESIS OF SEQUENCE-DEFINED POLYMER, 재단법인한국연구재단 (2023-2024)
  • , 포항공과대학교 (2023-2024)
  • , 과학기술정보통신부 (2023-2023)
  • , 포항공대산학협력단 (2023-2024)
  • , 포스코홀딩스(주) (2023-2024)
  • , 포스코홀딩스(주) (2023-2024)
  • 비정형단백질 대량생산을 위한 대장균유전체가공 및 세포파쇄액 내 특정효소 제거, 포항공대산학협력단 (2023-2024)
  • , 재단법인 경북바이오산업연구원 바이오벤처프라자 (2024-2024)
  • , 과학기술정보통신부 (2024-2024)
  • RIBOSOME-MEDIATED SYNTHESIS OF PROTEIN NANOPORES BEARING NON-CANONICAL AMINO ACIDS, 재단법인한국연구재단 (2024-2025)
  • REPURPOSING THE TRANSLATIONAL MACHINERY FOR THE SYNTHESIS OF SEQUENCE-DEFINED POLYMER, 재단법인한국연구재단 (2024-2025)
  • SYNTHESIS OF PRECISION POLYMERS USING XNA IN VITRO, 재단법인한국연구재단 (2024-2024)
  • , 재단법인한국연구재단 (2025-2025)

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